No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugs

• Published in: International Journal of Obesity 2007-06, Vol.31 (6), p.1014-1022
• Main Authors: Cope, M B, Jumbo-Lucioni, P, Walton, R G, Kesterson, R A, Allison, D B, Nagy, T R
• Format: Article
• Language: English
• Subjects: Adipose Tissue - physiology; Administration, Oral; Animals; Antipsychotic Agents - administration & dosage; Antipsychotic drugs; Antipsychotics; Benzodiazepines - administration & dosage; Biological and medical sciences; Body composition; Body Composition - physiology; Body weight; Bone Density - physiology; Care and treatment; Cholesterol; Diagnosis; Dibenzothiazepines - administration & dosage; Diet; Dietary Fats - administration & dosage; Dosage and administration; Drug Administration Schedule; Drug dosages; Drug therapy; Eating - physiology; Energy Intake - physiology; Epidemiology; Experiments; Feed conversion; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Health Promotion and Disease Prevention; Hyperlipidemia; Internal Medicine; Lipids; Lipids - blood; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Mice; Mice, Inbred C57BL; Nutrition; Obesity; Oils & fats; original-article; Psychotropic drugs; Public Health; Quetiapine Fumarate; Risk factors; Risperidone - administration & dosage; Schizophrenia; Variance analysis; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight Gain - drug effects; Weight Gain - physiology
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0803533

Rationale: Atypical antipsychotic drugs (AAD) induce significant weight gain in female C57BL/6J mice. The effect of dietary fat on weight gain and serum lipids in this model is unknown. Objectives: Test the hypothesis that the obesigenic effects of these drugs are greater in the presence of a high-fat diet. Methods: Female C57BL/6J mice were treated with atypical antipsychotics for 3 weeks and fed either a low-fat or high-fat diet (4.6 vs 15.6% fat by wt). Food intake (FI), body weight (BW), body composition, and serum lipids were measured during treatment with optimized doses of olanzapine, quetiapine, and risperidone. Energy intake (EI) and feed efficiency (FE) were calculated. Group differences in change were analyzed via repeated measures analysis of variance (ANOVA). Serum lipid concentrations, EI and FE were compared using two-way ANOVA. Results: AAD-treated mice gained significantly more weight than controls after 3 weeks ( P