Parathyroidectomy after successful kidney transplantation: a single centre study

Background. Successful kidney transplantation is believed to cure secondary hyperparathyroidism, but persistent disease has emerged in a significant number of allograft recipients. A parathyroidectomy is ultimately required in some of these patients. To gain insight into the incidence, risk factors...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2007-06, Vol.22 (6), p.1730-1737
Main Authors: Evenepoel, Pieter, Claes, Kathleen, Kuypers, Dirk R., Debruyne, Frans, Vanrenterghem, Yves
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Belgium - epidemiology
Biological and medical sciences
Case-Control Studies
Cohort Studies
Emergency and intensive care: renal failure. Dialysis management
Female
Humans
hyperparathyroidism
Hyperparathyroidism, Secondary - epidemiology
Hyperparathyroidism, Secondary - surgery
Incidence
Intensive care medicine
Kidney Transplantation
Kidneys
Male
Malformations of the urinary system
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Parathyroidectomy
Retrospective Studies
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
transplantation
Treatment Outcome
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Summary:Background. Successful kidney transplantation is believed to cure secondary hyperparathyroidism, but persistent disease has emerged in a significant number of allograft recipients. A parathyroidectomy is ultimately required in some of these patients. To gain insight into the incidence, risk factors and consequences of parathyroidectomy in patients with a functioning renal graft, we performed a retrospective case-controlled study. Methods. Charts of 1743 recipients of a kidney allograft, transplanted between 1989 and 2004, were reviewed. Patients with a functioning graft subjected to parathyroidectomy were identified. Their charts were checked for various demographic, clinical and biochemical variables. The data were compared with those obtained from patients transplanted in the same period, but not subjected to parathyroidectomy (controls). Results. Persistent hyperparathyroidism in patients with a functioning graft requiring parathyroidectomy developed in 90 patients, corresponding to an overall parathyroidectomy rate of 8.89 per 1000 person-years at risk. Female gender (OR 1.79, P 
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfm044