Highly Stable Pyrimidine-Motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue

Good things come in threes: A novel bridged nucleic acid in which the furanose conformation was locked in the N form by a six‐membered bridged moiety containing an NO bond (see picture) has been developed. Triplex‐forming oligonucleotides composed of this residue formed highly stable triplexes at p...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (23), p.4306-4309
Main Authors: Rahman, S. M. Abdur, Seki, Sayori, Obika, Satoshi, Haitani, Sunao, Miyashita, Kazuyuki, Imanishi, Takeshi
Format: Article
Language:English
Subjects:
bridged nucleic acids
Chemical Phenomena
Chemistry, Physical
Hydrogen-Ion Concentration
Molecular Conformation
Nucleic Acids - chemical synthesis
Nucleic Acids - chemistry
oligonucleotides
Pyrimidines - chemistry
Stereoisomerism
synthesis design
Temperature
thermal stability
triplexes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Good things come in threes: A novel bridged nucleic acid in which the furanose conformation was locked in the N form by a six‐membered bridged moiety containing an NO bond (see picture) has been developed. Triplex‐forming oligonucleotides composed of this residue formed highly stable triplexes at physiological pH values.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200604857