Herpes simplex virus type 1 (HSV-1)-induced retinitis following herpes simplex encephalitis: Indications for brain-to-eye transmission of HSV-1

Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV‐1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In th...

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Bibliographic Details
Published in:Annals of neurology 2001-01, Vol.49 (1), p.104-106
Main Authors: Maertzdorf, Jeroen, Van Der Lelij, Allegonda, Baarsma, G. Seerp, Osterhaus, Albert D. M. E., Verjans, Georges M. G. M.
Format: Article
Language:English
Subjects:
Aged
Base Sequence
Biological and medical sciences
DNA, Viral - genetics
Encephalitis, Herpes Simplex - genetics
Encephalitis, Herpes Simplex - transmission
Female
Herpesvirus 1, Human - genetics
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Retinitis - genetics
Viral diseases
Viral diseases of the nervous system
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Summary:Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV‐1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV‐1 strains in the brain and eye of 2 patients with acute retinal necrosis following an episode of herpes simplex encephalitis were genotyped. The HSV‐1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brain‐to‐eye transmission of HSV‐1 in these patients. Ann Neurol 2001;49:104–106
ISSN:0364-5134
1531-8249
DOI:10.1002/1531-8249(200101)49:1<104::AID-ANA15>3.0.CO;2-Y