Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection

Human immunodeficiency virus (HIV) infection is associated with a progressive dementia, in addition to motor and behavioural deficits. Cognitive deterioration and motor impairments have been observed also in simian immunodeficiency virus (SIV)-infected monkeys, an animal model for HIV infection. We...

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Bibliographic Details
Published in:European journal of pharmacology 2001-01, Vol.411 (1-2), p.R1-R2
Main Authors: Koutsilieri, Eleni, Scheller, Carsten, Sopper, Sieghart, Götz, Mario E, Gerlach, Manfred, Meulen, Volker ter, Riederer, Peter
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Anticonvulsants. Antiepileptics. Antiparkinson agents
Antiviral agents
Biological and medical sciences
Brain - drug effects
Brain - enzymology
Choline O-Acetyltransferase - drug effects
Choline O-Acetyltransferase - metabolism
Dementia
Dose-Response Relationship, Drug
Hippocampus - drug effects
Hippocampus - enzymology
Human immunodeficiency virus (HIV)
Macaca mulatta
Medical sciences
Monoamine Oxidase Inhibitors - pharmacology
Neuropharmacology
Pharmacology. Drug treatments
Putamen - drug effects
Putamen - enzymology
Selegiline
Selegiline - pharmacology
Simian Acquired Immunodeficiency Syndrome - enzymology
Simian Acquired Immunodeficiency Syndrome - virology
Simian Immunodeficiency Virus
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Summary:Human immunodeficiency virus (HIV) infection is associated with a progressive dementia, in addition to motor and behavioural deficits. Cognitive deterioration and motor impairments have been observed also in simian immunodeficiency virus (SIV)-infected monkeys, an animal model for HIV infection. We found recently that choline acetyltransferase activity is markedly reduced in brains of SIV-infected monkeys. We report now that selegiline, completely restores the reduced choline acetyltransferase activity which encourages for a meaningful anti-dementia therapeutic strategy.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(00)00874-8