CYP19 gene polymorphism in endometrial cancer patients

Initiation/promotion of endometrial cancer is known to be associated with estrogenic influence. Therefore, it is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to endometrial cancer susceptibility. Here, we compared CYP19 (aromatase...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2001-02, Vol.127 (2), p.135-138
Main Authors: Berstein, L M, Imyanitov, E N, Suspitsin, E N, Grigoriev, M Y, Sokolov, E P, Togo, A, Hanson, K P, Poroshina, T E, Vasiljev, D A, Kovalevskij, A Y, Gamajunova, V B
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Aromatase - genetics
Case-Control Studies
Endometrial Neoplasms - enzymology
Endometrial Neoplasms - genetics
Female
Genotype
Humans
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
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Summary:Initiation/promotion of endometrial cancer is known to be associated with estrogenic influence. Therefore, it is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to endometrial cancer susceptibility. Here, we compared CYP19 (aromatase) gene polymorphism in 85 endometrial cancer patients and in 110 non-affected women. The genotypes containing the longest alleles (A6 and A7) of CYP19 were found to be over-represented in patients as compared to controls. In addition, these genotypes demonstrated a tendency to be associated with increased concentrations of estradiol and testosterone in postmenopausal patients. Thus, CYP19 polymorphism might be one of the genetic risk factors for endometrial cancer development.
ISSN:0171-5216
1432-1335
DOI:10.1007/s004320000200