Effects of age and gender on the QT response to exercise

Although gender differences in resting corrected QT intervals have been well documented, the effects of age and exercise on gender differences in QT have not been well characterized. Data were analyzed from 91 healthy volunteers (47 women). Forty-five young subjects (aged 20 to 39 years) and 46 olde...

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Bibliographic Details
Published in:The American journal of cardiology 2001-01, Vol.87 (2), p.163-167
Main Authors: Mayuga, Kenneth A, Parker, Michelle, Sukthanker, Neeta D, Perlowski, Alice, Schwartz, Janice B, Kadish, Alan H
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Exercise
Exercise - physiology
Exercise Test
Female
Fundamental and applied biological sciences. Psychology
Gender
Heart
Heart - physiology
Heart Rate
Humans
Male
Mathematical models
Middle Aged
Models, Cardiovascular
Reference Values
Sex Factors
Vertebrates: cardiovascular system
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Summary:Although gender differences in resting corrected QT intervals have been well documented, the effects of age and exercise on gender differences in QT have not been well characterized. Data were analyzed from 91 healthy volunteers (47 women). Forty-five young subjects (aged 20 to 39 years) and 46 older subjects (61 to 84 years) were recruited. All underwent Bruce protocol stress testing. QT offset and QT peak were measured at exercise stages and during recovery. In a heart rate (HR)–independent analysis, data were divided into HR bins of 10 beats/min. In a HR-dependent analysis, 6 models were used to approximate the QT-RR relation; the best were used to analyze age and gender effects. Women had longer QT intervals than men at a HR
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)01309-6