Loading…
Effects of age and gender on the QT response to exercise
Although gender differences in resting corrected QT intervals have been well documented, the effects of age and exercise on gender differences in QT have not been well characterized. Data were analyzed from 91 healthy volunteers (47 women). Forty-five young subjects (aged 20 to 39 years) and 46 olde...
Saved in:
Published in: | The American journal of cardiology 2001-01, Vol.87 (2), p.163-167 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c482t-74c91bd90b534f5aa853b575d40c7ce512306cff981635d71f4e824b1721aaf3 |
---|---|
cites | cdi_FETCH-LOGICAL-c482t-74c91bd90b534f5aa853b575d40c7ce512306cff981635d71f4e824b1721aaf3 |
container_end_page | 167 |
container_issue | 2 |
container_start_page | 163 |
container_title | The American journal of cardiology |
container_volume | 87 |
creator | Mayuga, Kenneth A Parker, Michelle Sukthanker, Neeta D Perlowski, Alice Schwartz, Janice B Kadish, Alan H |
description | Although gender differences in resting corrected QT intervals have been well documented, the effects of age and exercise on gender differences in QT have not been well characterized. Data were analyzed from 91 healthy volunteers (47 women). Forty-five young subjects (aged 20 to 39 years) and 46 older subjects (61 to 84 years) were recruited. All underwent Bruce protocol stress testing. QT offset and QT peak were measured at exercise stages and during recovery. In a heart rate (HR)–independent analysis, data were divided into HR bins of 10 beats/min. In a HR-dependent analysis, 6 models were used to approximate the QT-RR relation; the best were used to analyze age and gender effects. Women had longer QT intervals than men at a HR |
doi_str_mv | 10.1016/S0002-9149(00)01309-6 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70599589</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002914900013096</els_id><sourcerecordid>70599589</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-74c91bd90b534f5aa853b575d40c7ce512306cff981635d71f4e824b1721aaf3</originalsourceid><addsrcrecordid>eNqFkdtKxDAQhoMouh4eQQkKohfVTNO0yZWIrAcQRNz7kKaTtbLbrElX9O3NHlDwxqth4Jt_hm8IOQR2AQzKyxfGWJ4pKNQZY-cMOFNZuUEGICuVgQK-SQY_yA7ZjfEttQCi3CY7kGoueT4gcugc2j5S76gZIzVdQ8fYNRio72j_ivR5RAPGme8i0t5T_MRg24j7ZMuZScSDdd0jo9vh6OY-e3y6e7i5fsxsIfM-qwqroG4UqwUvnDBGCl6LSjQFs5VFATlnpXVOSSi5aCpwBcq8qKHKwRjH98jpKnYW_PscY6-nbbQ4mZgO_TzqigmlhFQJPP4Dvvl56NJpOq3gJYcKEiRWkA0-xoBOz0I7NeFLA9MLrXqpVS-cacb0Uqsu09zROnxeT7H5nVp7TMDJGjDRmokLpkuSfjgpVC4WMVcrCpOwjxaDjrbFzmLThvQE3fj2n0O-AVg_kGI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230363171</pqid></control><display><type>article</type><title>Effects of age and gender on the QT response to exercise</title><source>ScienceDirect Journals</source><creator>Mayuga, Kenneth A ; Parker, Michelle ; Sukthanker, Neeta D ; Perlowski, Alice ; Schwartz, Janice B ; Kadish, Alan H</creator><creatorcontrib>Mayuga, Kenneth A ; Parker, Michelle ; Sukthanker, Neeta D ; Perlowski, Alice ; Schwartz, Janice B ; Kadish, Alan H</creatorcontrib><description>Although gender differences in resting corrected QT intervals have been well documented, the effects of age and exercise on gender differences in QT have not been well characterized. Data were analyzed from 91 healthy volunteers (47 women). Forty-five young subjects (aged 20 to 39 years) and 46 older subjects (61 to 84 years) were recruited. All underwent Bruce protocol stress testing. QT offset and QT peak were measured at exercise stages and during recovery. In a heart rate (HR)–independent analysis, data were divided into HR bins of 10 beats/min. In a HR-dependent analysis, 6 models were used to approximate the QT-RR relation; the best were used to analyze age and gender effects. Women had longer QT intervals than men at a HR <100 beats/min for QT offset and <110 beats/min for QT peak. At faster HRs, no significant differences were found. Older subjects had slightly longer QT intervals than the younger group, with a mean difference of 2 ms for QT offset and 9 ms for QT peak. Women had increased constant and slope coefficients. The QT increase in the elderly was relatively small. Gender differences in QT disappear at faster HRs, whereas age differences are smaller but are present throughout exercise, with no significant age–gender interaction. A natural logarithmic model provides the best approximation of the QT-RR relation with exercise, is simple to implement, and should become the preferred method of QT correction.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(00)01309-6</identifier><identifier>PMID: 11152832</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Exercise ; Exercise - physiology ; Exercise Test ; Female ; Fundamental and applied biological sciences. Psychology ; Gender ; Heart ; Heart - physiology ; Heart Rate ; Humans ; Male ; Mathematical models ; Middle Aged ; Models, Cardiovascular ; Reference Values ; Sex Factors ; Vertebrates: cardiovascular system</subject><ispartof>The American journal of cardiology, 2001-01, Vol.87 (2), p.163-167</ispartof><rights>2001 Excerpta Medica Inc.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Jan 15, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-74c91bd90b534f5aa853b575d40c7ce512306cff981635d71f4e824b1721aaf3</citedby><cites>FETCH-LOGICAL-c482t-74c91bd90b534f5aa853b575d40c7ce512306cff981635d71f4e824b1721aaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=859256$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11152832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mayuga, Kenneth A</creatorcontrib><creatorcontrib>Parker, Michelle</creatorcontrib><creatorcontrib>Sukthanker, Neeta D</creatorcontrib><creatorcontrib>Perlowski, Alice</creatorcontrib><creatorcontrib>Schwartz, Janice B</creatorcontrib><creatorcontrib>Kadish, Alan H</creatorcontrib><title>Effects of age and gender on the QT response to exercise</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Although gender differences in resting corrected QT intervals have been well documented, the effects of age and exercise on gender differences in QT have not been well characterized. Data were analyzed from 91 healthy volunteers (47 women). Forty-five young subjects (aged 20 to 39 years) and 46 older subjects (61 to 84 years) were recruited. All underwent Bruce protocol stress testing. QT offset and QT peak were measured at exercise stages and during recovery. In a heart rate (HR)–independent analysis, data were divided into HR bins of 10 beats/min. In a HR-dependent analysis, 6 models were used to approximate the QT-RR relation; the best were used to analyze age and gender effects. Women had longer QT intervals than men at a HR <100 beats/min for QT offset and <110 beats/min for QT peak. At faster HRs, no significant differences were found. Older subjects had slightly longer QT intervals than the younger group, with a mean difference of 2 ms for QT offset and 9 ms for QT peak. Women had increased constant and slope coefficients. The QT increase in the elderly was relatively small. Gender differences in QT disappear at faster HRs, whereas age differences are smaller but are present throughout exercise, with no significant age–gender interaction. A natural logarithmic model provides the best approximation of the QT-RR relation with exercise, is simple to implement, and should become the preferred method of QT correction.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gender</subject><subject>Heart</subject><subject>Heart - physiology</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Middle Aged</subject><subject>Models, Cardiovascular</subject><subject>Reference Values</subject><subject>Sex Factors</subject><subject>Vertebrates: cardiovascular system</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkdtKxDAQhoMouh4eQQkKohfVTNO0yZWIrAcQRNz7kKaTtbLbrElX9O3NHlDwxqth4Jt_hm8IOQR2AQzKyxfGWJ4pKNQZY-cMOFNZuUEGICuVgQK-SQY_yA7ZjfEttQCi3CY7kGoueT4gcugc2j5S76gZIzVdQ8fYNRio72j_ivR5RAPGme8i0t5T_MRg24j7ZMuZScSDdd0jo9vh6OY-e3y6e7i5fsxsIfM-qwqroG4UqwUvnDBGCl6LSjQFs5VFATlnpXVOSSi5aCpwBcq8qKHKwRjH98jpKnYW_PscY6-nbbQ4mZgO_TzqigmlhFQJPP4Dvvl56NJpOq3gJYcKEiRWkA0-xoBOz0I7NeFLA9MLrXqpVS-cacb0Uqsu09zROnxeT7H5nVp7TMDJGjDRmokLpkuSfjgpVC4WMVcrCpOwjxaDjrbFzmLThvQE3fj2n0O-AVg_kGI</recordid><startdate>20010115</startdate><enddate>20010115</enddate><creator>Mayuga, Kenneth A</creator><creator>Parker, Michelle</creator><creator>Sukthanker, Neeta D</creator><creator>Perlowski, Alice</creator><creator>Schwartz, Janice B</creator><creator>Kadish, Alan H</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010115</creationdate><title>Effects of age and gender on the QT response to exercise</title><author>Mayuga, Kenneth A ; Parker, Michelle ; Sukthanker, Neeta D ; Perlowski, Alice ; Schwartz, Janice B ; Kadish, Alan H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-74c91bd90b534f5aa853b575d40c7ce512306cff981635d71f4e824b1721aaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gender</topic><topic>Heart</topic><topic>Heart - physiology</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Middle Aged</topic><topic>Models, Cardiovascular</topic><topic>Reference Values</topic><topic>Sex Factors</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mayuga, Kenneth A</creatorcontrib><creatorcontrib>Parker, Michelle</creatorcontrib><creatorcontrib>Sukthanker, Neeta D</creatorcontrib><creatorcontrib>Perlowski, Alice</creatorcontrib><creatorcontrib>Schwartz, Janice B</creatorcontrib><creatorcontrib>Kadish, Alan H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mayuga, Kenneth A</au><au>Parker, Michelle</au><au>Sukthanker, Neeta D</au><au>Perlowski, Alice</au><au>Schwartz, Janice B</au><au>Kadish, Alan H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of age and gender on the QT response to exercise</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2001-01-15</date><risdate>2001</risdate><volume>87</volume><issue>2</issue><spage>163</spage><epage>167</epage><pages>163-167</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Although gender differences in resting corrected QT intervals have been well documented, the effects of age and exercise on gender differences in QT have not been well characterized. Data were analyzed from 91 healthy volunteers (47 women). Forty-five young subjects (aged 20 to 39 years) and 46 older subjects (61 to 84 years) were recruited. All underwent Bruce protocol stress testing. QT offset and QT peak were measured at exercise stages and during recovery. In a heart rate (HR)–independent analysis, data were divided into HR bins of 10 beats/min. In a HR-dependent analysis, 6 models were used to approximate the QT-RR relation; the best were used to analyze age and gender effects. Women had longer QT intervals than men at a HR <100 beats/min for QT offset and <110 beats/min for QT peak. At faster HRs, no significant differences were found. Older subjects had slightly longer QT intervals than the younger group, with a mean difference of 2 ms for QT offset and 9 ms for QT peak. Women had increased constant and slope coefficients. The QT increase in the elderly was relatively small. Gender differences in QT disappear at faster HRs, whereas age differences are smaller but are present throughout exercise, with no significant age–gender interaction. A natural logarithmic model provides the best approximation of the QT-RR relation with exercise, is simple to implement, and should become the preferred method of QT correction.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11152832</pmid><doi>10.1016/S0002-9149(00)01309-6</doi><tpages>5</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0002-9149 |
ispartof | The American journal of cardiology, 2001-01, Vol.87 (2), p.163-167 |
issn | 0002-9149 1879-1913 |
language | eng |
recordid | cdi_proquest_miscellaneous_70599589 |
source | ScienceDirect Journals |
subjects | Adult Age Age Factors Aged Aged, 80 and over Biological and medical sciences Exercise Exercise - physiology Exercise Test Female Fundamental and applied biological sciences. Psychology Gender Heart Heart - physiology Heart Rate Humans Male Mathematical models Middle Aged Models, Cardiovascular Reference Values Sex Factors Vertebrates: cardiovascular system |
title | Effects of age and gender on the QT response to exercise |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T20%3A31%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20age%20and%20gender%20on%20the%20QT%20response%20to%20exercise&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Mayuga,%20Kenneth%20A&rft.date=2001-01-15&rft.volume=87&rft.issue=2&rft.spage=163&rft.epage=167&rft.pages=163-167&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/S0002-9149(00)01309-6&rft_dat=%3Cproquest_cross%3E70599589%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c482t-74c91bd90b534f5aa853b575d40c7ce512306cff981635d71f4e824b1721aaf3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=230363171&rft_id=info:pmid/11152832&rfr_iscdi=true |