Selective Cardiac Neuroadrenergic Abnormalities in Hypertensive Patients with Left Ventricular Hypertrophy

Background Increased sympathetic drive to the heart might contribute to the development and progression of myocardial damage in hypertensive patients (HTs). This study assessed the possible presence of abnormalities in myocardial uptake of123 I-metaiodobenzylguanidine (MIBG), a marker of sympathetic...

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Bibliographic Details
Published in:Archives of medical research 2007-07, Vol.38 (5), p.512-518
Main Authors: Giordano, Alessandro, Melina, Giovanni, Calcagni, Maria Lucia, Schinzari, Francesca, Cirillo, Fiammetta, Mettimano, Marco, Cardillo, Carmine, Melina, Domenico
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Echocardiography
Essential hypertension
Female
Heart
Humans
Hypertension - diagnostic imaging
Hypertension - physiopathology
Hypertrophy, Left Ventricular - blood
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - physiopathology
Internal Medicine
Iodine Radioisotopes
Left ventricular hypertrophy
Male
Metaiodobenzylguanidine
Middle Aged
Myocardial Ischemia - diagnostic imaging
Radionuclide Imaging
Scintigraphy
Sympathetic Nervous System - diagnostic imaging
Thallium Radioisotopes
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Summary:Background Increased sympathetic drive to the heart might contribute to the development and progression of myocardial damage in hypertensive patients (HTs). This study assessed the possible presence of abnormalities in myocardial uptake of123 I-metaiodobenzylguanidine (MIBG), a marker of sympathetic activity, in HTs with left ventricular hypertrophy (LVH). Methods Eleven HTs with LVH and 10 matched normotensive controls underwent clinical and laboratory examination, as well as LVH determination by echocardiography. The presence of myocardial ischemia was ruled out by exercise stress testing. Global and regional myocardial uptake of123 I-MIBG was determined in both groups using planar and single proton emission tomography scintigraphy. In addition, thallium-201 (Tl-201) myocardial scintigraphy was performed in HTs. The heart/mediastinum (H/M) ratio on planar123 I-MIBG images at different time points was compared between HTs and controls. Moreover, regional cardiac uptake of123 I-MIBG was compared between groups and, within the HTs group, with regional Tl-201 uptake. Results At all study times, the H/M ratio was lower in HTs than in controls (all p
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2007.01.009