Functional imaging of the brain in sedated newborn infants using near infrared topography during passive knee movement

Near infrared topography was used for functional imaging of the sensorimotor cortex of newborn infants during passive knee movement under sedated sleep. Contralateral knee movement caused a marked increase in oxyhemoglobin and total hemoglobin from the baseline values at almost all locations in the...

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Bibliographic Details
Published in:Neuroscience letters 2001-02, Vol.299 (3), p.221-224
Main Authors: Isobe, Kenichi, Kusaka, Takashi, Nagano, Keiko, Okubo, Kensuke, Yasuda, Saneyuki, Kondo, Masatoshi, Itoh, Susumu, Onishi, Shoju
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain Mapping - methods
Cerebrovascular Circulation - drug effects
Cerebrovascular Circulation - physiology
Functional imaging
Functional Laterality - physiology
Fundamental and applied biological sciences. Psychology
Hemoglobins - metabolism
Human
Humans
Hypnotics and Sedatives - pharmacology
Infant, Newborn
Knee Joint - innervation
Knee Joint - physiology
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Movement - physiology
Near infrared spectroscopy
near infrared topography
Neonate
Passive movement
Primary sensorimotor cortex
Range of Motion, Articular - physiology
Somatosensory Cortex - anatomy & histology
Somatosensory Cortex - drug effects
Somatosensory Cortex - metabolism
Spectroscopy, Near-Infrared - methods
Thiamylal - pharmacology
Topography
Vertebrates: nervous system and sense organs
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Summary:Near infrared topography was used for functional imaging of the sensorimotor cortex of newborn infants during passive knee movement under sedated sleep. Contralateral knee movement caused a marked increase in oxyhemoglobin and total hemoglobin from the baseline values at almost all locations in the primary sensorimotor area of all neonates and a decrease in local deoxyhemoglobin in six of seven neonates. During ipsilateral knee movement, oxyhemoglobin and total hemoglobin showed slighter changes at a few locations, equal to 30% (mean) and 29% (mean) of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes were 11.9 s for oxyhemoglobin and 19.1 s for deoxyhemoglobin, demonstrating that oxyhemoglobin has a much faster response than does deoxyhemoglobin.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(01)01518-X