Paclitaxel and Cisplatin with Concurrent Radiotherapy followed by Surgery in Locally Advanced Thymic Carcinoma

Thymic carcinoma is a rare neoplasm with a poor prognosis. We report the clinical course of a patient who received complete surgical resection after effective induction treatment. A 72-year-old woman with advanced thymic carcinoma (squamous cell carcinoma, stage IVb) was considered as nonresectable...

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Bibliographic Details
Published in:Anticancer research 2007-05, Vol.27 (3B), p.1601-1604
Main Authors: FUKUDA, Minoru, OBASE, Yasushi, OKA, Mikio, MIYASHITA, Naoyuki, KOBASHI, Yoshihiro, MOHRI, Keiji, UENO, Shiro, HAYAMA, Makio, SHIMIZU, Katsuhiko, NISHIMURA, Hironori, NAKATA, Masao
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Cisplatin - administration & dosage
Cisplatin - therapeutic use
Combined Modality Therapy
Female
Humans
Medical sciences
Paclitaxel - administration & dosage
Paclitaxel - therapeutic use
Pneumology
Radiography, Thoracic
Thymoma - drug therapy
Thymoma - radiotherapy
Thymoma - surgery
Thymus Neoplasms - drug therapy
Thymus Neoplasms - radiotherapy
Thymus Neoplasms - surgery
Treatment Outcome
Tumors
Tumors of the respiratory system and mediastinum
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Summary:Thymic carcinoma is a rare neoplasm with a poor prognosis. We report the clinical course of a patient who received complete surgical resection after effective induction treatment. A 72-year-old woman with advanced thymic carcinoma (squamous cell carcinoma, stage IVb) was considered as nonresectable due to invasion of neighboring organs and mediastinal lymph node metastasis. Two cycles of chemotherapy, consisting of paclitaxel (180 mg/m 2 ) plus cisplatin (80 mg/m 2 ), combined with thoracic radiotherapy (total 54 Gy) were performed concurrently and complete radical resection could then be performed. She is currently alive and ambulatory and has remained disease-free for two years. This multimodal treatment may be a good treatment option for locally advanced thymic carcinoma.
ISSN:0250-7005
1791-7530