Monitoring xenotransplant recipients for infection by PERV

Objectives: Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus ( PERV) to porcine xenograft recipients. Methods: To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell...

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Bibliographic Details
Published in:Clinical biochemistry 2001-02, Vol.34 (1), p.23-27
Main Authors: Herring, Chris, Cunningham, Deirdre A, Whittam, Alison J, Fernández-Suárez, Xosé M, Langford, Gillian A
Format: Article
Language:English
Subjects:
Animals
Chemistry, Clinical - methods
DNA, Viral - analysis
Humans
microchimerism
Patient monitoring
pigs
Porcine endogenous retrovirus
Retrospective Studies
Retroviridae - metabolism
Retroviridae Infections - diagnosis
Retroviridae Infections - transmission
Reverse Transcriptase Polymerase Chain Reaction
Review
Swine
Transplantation, Heterologous - adverse effects
Xenotransplantation
Xenozoonosis
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Summary:Objectives: Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus ( PERV) to porcine xenograft recipients. Methods: To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell microchimerism have been developed by a number of groups. Retrospective studies of patients exposed to living pig tissues have been performed using these assays to look for evidence of cross species transmission. Results: To date no evidence of PERV infection has been found in studies of humans exposed to pig tissues, despite evidence of long lived microchimerism. Conclusions: These data suggest that PERV infection has not occurred in a clinical setting. However, as infection has been seen in a small animal model further investigation of the risk from PERV is warranted.
ISSN:0009-9120
1873-2933
DOI:10.1016/S0009-9120(00)00187-9