Management of hepatocellular carcinoma in human immunodeficiency virus-infected patients

Hepatocellular carcinoma (HCC) resulting from chronic infection with hepatitis B or C virus (HBV, HCV) is a significant health problem. Concurrent infection with human immunodeficiency virus (HIV) may accelerate the progression from cirrhosis to HCC. Current guidelines advise screening patients with...

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Bibliographic Details
Published in:Journal of hepatology 2006, Vol.44 (1 Suppl), p.S146-S150
Main Authors: Bruno, Raffaele, Puoti, Massimo, Sacchi, Paolo, Filice, Carlo, Carosi, Giampiero, Filice, Gaetano
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - therapy
Chemoembolization, Therapeutic - methods
Cirrhosis
HCC
Hepatectomy
Hepatitis B
Hepatitis C
HIV
HIV Infections - complications
HIV-1
Humans
Liver Neoplasms - complications
Liver Neoplasms - therapy
Liver Transplantation
Treatment Outcome
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Summary:Hepatocellular carcinoma (HCC) resulting from chronic infection with hepatitis B or C virus (HBV, HCV) is a significant health problem. Concurrent infection with human immunodeficiency virus (HIV) may accelerate the progression from cirrhosis to HCC. Current guidelines advise screening patients with cirrhosis at 6-month intervals using ultrasonography and measurement of alpha-fetoprotein levels. In early-stage HCC, resection and liver transplantation are curative, as is percutaneous ethanol injection for small tumours in patients who are not candidates for surgery. HIV-infected patients do not qualify for liver transplantation. For late-stage HCC, chemoembolization can improve survival. Prevention of hepatitis and cirrhosis are key goals in reducing the impact of HCC. Numerous issues in HCC prevention, diagnosis, and management still remain to be resolved through large-scale, randomized clinical trials.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2005.11.029