Sustained reverse left ventricular structural remodeling with cardiac resynchronization at one year is a function of etiology : Quantitative doppler echocardiographic evidence from the multicenter insync randomized clinical evaluation (MIRACLE)

Cardiac resynchronization therapy (CRT) is an effective therapy for patients with moderate to severe heart failure and prolonged QRS duration. The purpose of this study was to determine whether reverse left ventricular (LV) remodeling and symptomatic benefit from CRT were sustained at 12 months, and...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2006-01, Vol.113 (2), p.266-272
Main Authors: SUTTON, Martin G. St John, PLAPPERT, Ted, HILPISCH, Kathryn E, ABRAHAM, William T, HAYES, David L, CHINCHOY, Edward
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Blood and lymphatic vessels
Cardiac Pacing, Artificial
Cardiology. Vascular system
Cardiovascular system
Cohort Studies
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Echocardiography, Doppler
Female
Follow-Up Studies
Heart
Heart Failure - etiology
Heart Failure - therapy
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Heart Function Tests
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myocardial Ischemia
Ultrasonic investigative techniques
Ventricular Remodeling
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Summary:Cardiac resynchronization therapy (CRT) is an effective therapy for patients with moderate to severe heart failure and prolonged QRS duration. The purpose of this study was to determine whether reverse left ventricular (LV) remodeling and symptomatic benefit from CRT were sustained at 12 months, and if so, in what proportion of patients this occurred. Serial Doppler echocardiograms were obtained at baseline and 6 and 12 months after CRT in 228 patients enrolled in the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) trial. Measurements were made of LV end-diastolic (EDV) and end-systolic (ESV) volumes, ejection fraction, LV mass, severity of mitral regurgitation (MR), peak transmitral velocities during early (E wave) and late (A wave) diastolic filling, and myocardial performance index. At both 6 and 12 months, respectively, CRT was associated with reduced LV EDV (P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.104.520817