Takayasu’s arteritis: Operative results and influence of disease activity

To determine the short- and long-term outcomes of patients treated operatively for Takayasu’s arteritis and the effect of disease activity on results. Forty-two (17%) of the 251 patients enrolled in our Takayasu’s arteritis registry between 1975 and 2002 required operation for symptomatic disease. D...

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Bibliographic Details
Published in:Journal of vascular surgery 2006-01, Vol.43 (1), p.64-71
Main Authors: Fields, Charles E., Bower, Thomas C., Cooper, Leslie T., Hoskin, Tanya, Noel, Audra A., Panneton, Jean M., Sullivan, Timothy M., Gloviczki, Peter, Cherry, Kenneth J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Disease Progression
Female
Follow-Up Studies
Humans
Male
Middle Aged
Takayasu Arteritis - diagnosis
Takayasu Arteritis - surgery
Time Factors
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Summary:To determine the short- and long-term outcomes of patients treated operatively for Takayasu’s arteritis and the effect of disease activity on results. Forty-two (17%) of the 251 patients enrolled in our Takayasu’s arteritis registry between 1975 and 2002 required operation for symptomatic disease. Data were obtained from the registry, patient records, phone correspondence, and written surveys. There were 38 females and 4 males with a median age of 29 years (range, 12 to 56 years), and 32 (76%) were white. Sixty operations were performed for symptomatic disease. The mean duration of symptoms before operation was 5.6 months (range, 0 to 25 months). Thirteen (31%) patients had active disease and underwent operation for acute presentation or failure of medical management. Thirty-nine patients (93%) had operation for occlusive disease. Twenty-two (52%) patients had involvement of both the great and abdominal aortic branch vessels; 10 (24%) had great vessel disease alone; 9 (21%) had involvement of abdominal arteries; and 1 (2%) had coronary artery disease. There was no operative death, myocardial infarction, major stroke, or renal failure. Three patients had early graft thrombosis, two had a minor stroke, and two developed hyperperfusion syndrome. The median follow-up was 6.7 years (range, 1 month to 19.3 years). Eleven (26%) patients required 15 graft revisions; five of the patients had active disease at the time of initial operation. All early revisions (
ISSN:0741-5214
1097-6809
DOI:10.1016/j.jvs.2005.10.010