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Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice
Gastrodia elata Blume (GEB) is a traditional herbal plant that has been used in Asian countries for centuries as an anticonvulsant, analgesic, and also as a sedative for treating general paralysis, epilepsy, vertigo, and tetanus. Although numerous reports have addressed the effects of GEB against de...
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| Published in: | International journal of molecular medicine 2007-08, Vol.20 (2), p.209-215 |
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| container_end_page | 215 |
| container_issue | 2 |
| container_start_page | 209 |
| container_title | International journal of molecular medicine |
| container_volume | 20 |
| creator | An, Sang-Mi Park, Chul-Hong Heo, Jin-Chul Park, Ja-Young Woo, Sang-Uk Seo, Ji-Hye Lee, Mi-Soon Cho, Kang-Jin Cho, Hyun-Suk Shin, Heung Lee, Sang-Han |
| description | Gastrodia elata Blume (GEB) is a traditional herbal plant that has been
used in Asian countries for centuries as an anticonvulsant, analgesic, and also
as a sedative for treating general paralysis, epilepsy, vertigo, and tetanus.
Although numerous reports have addressed the effects of GEB against degenerative
diseases, no previous study has examined the possible gastroprotective effects
of GEB. Here, we examined the effects of pretreatment with GEB (0.02 ml/g, p.o.)
in a mouse water immersion restraint (WIR) stress-induced gastric lesion model.
Our results revealed that mice pretreated with GEB had significantly fewer gastric
lesions than their respective controls. Moreover, GEB-treated mice showed significant
decreases in serum and gastric nitric oxide (NO) levels to 50 and 28%, respectively.
To examine one possible mechanism underlying this effect, we used reverse transcription-polymerase
chain reaction (RT-PCR) to examine NOS mRNA expression in gastric lesion tissues.
Our results revealed that the mRNA expression of inducible nitric oxide synthase
(iNOS) was reduced by ≈50% in GEB-pretreated mice versus the controls, whereas
the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal
nitric oxide synthase (nNOS) remained unchanged. These findings collectively suggest
that GEB significantly protects the gastric mucosa against WIR-induced gastric
damage, at least in part by decreasing NO levels via suppression of iNOS mRNA
expression. |
| doi_str_mv | 10.3892/ijmm.20.2.209 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70684881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70684881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-fc0e7350bc23bdd76c79e7a2eab6d7021c119f0c3ae8db6b59aa97b794335b833</originalsourceid><addsrcrecordid>eNpFkD1PwzAQhi0EolAYWZEnFpTij8SOR6igIFVioRJb5NjXylWclFwy8O9x1aIu793w3KvTQ8gdZzNZGvEUtjHOBJuJFOaMXHFteCby_Ps87ZzpTOpCTcg14pYxUeSmvCQTrhXnSporslpYHPrOB0uhsYOlL80Yge76bgA3ILUbG1ocaIIAMQutHx14utlfBUfj6Dq0DW0AQ9ciDS2NwcENuVjbBuH2OKdk9fb6NX_Plp-Lj_nzMnNSqSFbOwZaFqx2Qtbea-W0AW0F2Fp5zQR3nJs1c9JC6WtVF8Zao2ttcimLupRySh4OvenfnxFwqGJAB01jW-hGrDRTZV6WPIHZAXR9h9jDutr1Idr-t-Ks2nus9h4rwSqRwiT-_lg81hH8iT6KS8DjAcCdbX3wHZ6Yf-uCidQleCH_AKiYfZQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70684881</pqid></control><display><type>article</type><title>Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice</title><source>Alma/SFX Local Collection</source><creator>An, Sang-Mi ; Park, Chul-Hong ; Heo, Jin-Chul ; Park, Ja-Young ; Woo, Sang-Uk ; Seo, Ji-Hye ; Lee, Mi-Soon ; Cho, Kang-Jin ; Cho, Hyun-Suk ; Shin, Heung ; Lee, Sang-Han</creator><creatorcontrib>An, Sang-Mi ; Park, Chul-Hong ; Heo, Jin-Chul ; Park, Ja-Young ; Woo, Sang-Uk ; Seo, Ji-Hye ; Lee, Mi-Soon ; Cho, Kang-Jin ; Cho, Hyun-Suk ; Shin, Heung ; Lee, Sang-Han</creatorcontrib><description>Gastrodia elata Blume (GEB) is a traditional herbal plant that has been
used in Asian countries for centuries as an anticonvulsant, analgesic, and also
as a sedative for treating general paralysis, epilepsy, vertigo, and tetanus.
Although numerous reports have addressed the effects of GEB against degenerative
diseases, no previous study has examined the possible gastroprotective effects
of GEB. Here, we examined the effects of pretreatment with GEB (0.02 ml/g, p.o.)
in a mouse water immersion restraint (WIR) stress-induced gastric lesion model.
Our results revealed that mice pretreated with GEB had significantly fewer gastric
lesions than their respective controls. Moreover, GEB-treated mice showed significant
decreases in serum and gastric nitric oxide (NO) levels to 50 and 28%, respectively.
To examine one possible mechanism underlying this effect, we used reverse transcription-polymerase
chain reaction (RT-PCR) to examine NOS mRNA expression in gastric lesion tissues.
Our results revealed that the mRNA expression of inducible nitric oxide synthase
(iNOS) was reduced by ≈50% in GEB-pretreated mice versus the controls, whereas
the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal
nitric oxide synthase (nNOS) remained unchanged. These findings collectively suggest
that GEB significantly protects the gastric mucosa against WIR-induced gastric
damage, at least in part by decreasing NO levels via suppression of iNOS mRNA
expression.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.20.2.209</identifier><identifier>PMID: 17611639</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Animals ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Gastric Mucosa - chemistry ; Gastric Mucosa - drug effects ; Gastric Mucosa - pathology ; Gastrodia ; Gene Expression Regulation - drug effects ; Immersion ; Male ; Mice ; Mice, Inbred BALB C ; Nitric Oxide - analysis ; Nitric Oxide - blood ; Nitric Oxide Synthase Type I - genetics ; Nitric Oxide Synthase Type I - metabolism ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type II - metabolism ; Nitric Oxide Synthase Type III ; Restraint, Physical ; RNA, Messenger - analysis ; Stomach Diseases - pathology ; Stomach Diseases - prevention & control ; Stress, Physiological</subject><ispartof>International journal of molecular medicine, 2007-08, Vol.20 (2), p.209-215</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-fc0e7350bc23bdd76c79e7a2eab6d7021c119f0c3ae8db6b59aa97b794335b833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17611639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Sang-Mi</creatorcontrib><creatorcontrib>Park, Chul-Hong</creatorcontrib><creatorcontrib>Heo, Jin-Chul</creatorcontrib><creatorcontrib>Park, Ja-Young</creatorcontrib><creatorcontrib>Woo, Sang-Uk</creatorcontrib><creatorcontrib>Seo, Ji-Hye</creatorcontrib><creatorcontrib>Lee, Mi-Soon</creatorcontrib><creatorcontrib>Cho, Kang-Jin</creatorcontrib><creatorcontrib>Cho, Hyun-Suk</creatorcontrib><creatorcontrib>Shin, Heung</creatorcontrib><creatorcontrib>Lee, Sang-Han</creatorcontrib><title>Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>Gastrodia elata Blume (GEB) is a traditional herbal plant that has been
used in Asian countries for centuries as an anticonvulsant, analgesic, and also
as a sedative for treating general paralysis, epilepsy, vertigo, and tetanus.
Although numerous reports have addressed the effects of GEB against degenerative
diseases, no previous study has examined the possible gastroprotective effects
of GEB. Here, we examined the effects of pretreatment with GEB (0.02 ml/g, p.o.)
in a mouse water immersion restraint (WIR) stress-induced gastric lesion model.
Our results revealed that mice pretreated with GEB had significantly fewer gastric
lesions than their respective controls. Moreover, GEB-treated mice showed significant
decreases in serum and gastric nitric oxide (NO) levels to 50 and 28%, respectively.
To examine one possible mechanism underlying this effect, we used reverse transcription-polymerase
chain reaction (RT-PCR) to examine NOS mRNA expression in gastric lesion tissues.
Our results revealed that the mRNA expression of inducible nitric oxide synthase
(iNOS) was reduced by ≈50% in GEB-pretreated mice versus the controls, whereas
the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal
nitric oxide synthase (nNOS) remained unchanged. These findings collectively suggest
that GEB significantly protects the gastric mucosa against WIR-induced gastric
damage, at least in part by decreasing NO levels via suppression of iNOS mRNA
expression.</description><subject>Animals</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Gastric Mucosa - chemistry</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastrodia</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Immersion</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - blood</subject><subject>Nitric Oxide Synthase Type I - genetics</subject><subject>Nitric Oxide Synthase Type I - metabolism</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Restraint, Physical</subject><subject>RNA, Messenger - analysis</subject><subject>Stomach Diseases - pathology</subject><subject>Stomach Diseases - prevention & control</subject><subject>Stress, Physiological</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpFkD1PwzAQhi0EolAYWZEnFpTij8SOR6igIFVioRJb5NjXylWclFwy8O9x1aIu793w3KvTQ8gdZzNZGvEUtjHOBJuJFOaMXHFteCby_Ps87ZzpTOpCTcg14pYxUeSmvCQTrhXnSporslpYHPrOB0uhsYOlL80Yge76bgA3ILUbG1ocaIIAMQutHx14utlfBUfj6Dq0DW0AQ9ciDS2NwcENuVjbBuH2OKdk9fb6NX_Plp-Lj_nzMnNSqSFbOwZaFqx2Qtbea-W0AW0F2Fp5zQR3nJs1c9JC6WtVF8Zao2ttcimLupRySh4OvenfnxFwqGJAB01jW-hGrDRTZV6WPIHZAXR9h9jDutr1Idr-t-Ks2nus9h4rwSqRwiT-_lg81hH8iT6KS8DjAcCdbX3wHZ6Yf-uCidQleCH_AKiYfZQ</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>An, Sang-Mi</creator><creator>Park, Chul-Hong</creator><creator>Heo, Jin-Chul</creator><creator>Park, Ja-Young</creator><creator>Woo, Sang-Uk</creator><creator>Seo, Ji-Hye</creator><creator>Lee, Mi-Soon</creator><creator>Cho, Kang-Jin</creator><creator>Cho, Hyun-Suk</creator><creator>Shin, Heung</creator><creator>Lee, Sang-Han</creator><general>D.A. Spandidos</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice</title><author>An, Sang-Mi ; Park, Chul-Hong ; Heo, Jin-Chul ; Park, Ja-Young ; Woo, Sang-Uk ; Seo, Ji-Hye ; Lee, Mi-Soon ; Cho, Kang-Jin ; Cho, Hyun-Suk ; Shin, Heung ; Lee, Sang-Han</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-fc0e7350bc23bdd76c79e7a2eab6d7021c119f0c3ae8db6b59aa97b794335b833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Gastric Mucosa - chemistry</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastrodia</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Immersion</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - blood</topic><topic>Nitric Oxide Synthase Type I - genetics</topic><topic>Nitric Oxide Synthase Type I - metabolism</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Restraint, Physical</topic><topic>RNA, Messenger - analysis</topic><topic>Stomach Diseases - pathology</topic><topic>Stomach Diseases - prevention & control</topic><topic>Stress, Physiological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>An, Sang-Mi</creatorcontrib><creatorcontrib>Park, Chul-Hong</creatorcontrib><creatorcontrib>Heo, Jin-Chul</creatorcontrib><creatorcontrib>Park, Ja-Young</creatorcontrib><creatorcontrib>Woo, Sang-Uk</creatorcontrib><creatorcontrib>Seo, Ji-Hye</creatorcontrib><creatorcontrib>Lee, Mi-Soon</creatorcontrib><creatorcontrib>Cho, Kang-Jin</creatorcontrib><creatorcontrib>Cho, Hyun-Suk</creatorcontrib><creatorcontrib>Shin, Heung</creatorcontrib><creatorcontrib>Lee, Sang-Han</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, Sang-Mi</au><au>Park, Chul-Hong</au><au>Heo, Jin-Chul</au><au>Park, Ja-Young</au><au>Woo, Sang-Uk</au><au>Seo, Ji-Hye</au><au>Lee, Mi-Soon</au><au>Cho, Kang-Jin</au><au>Cho, Hyun-Suk</au><au>Shin, Heung</au><au>Lee, Sang-Han</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice</atitle><jtitle>International journal of molecular medicine</jtitle><addtitle>Int J Mol Med</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>20</volume><issue>2</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>1107-3756</issn><eissn>1791-244X</eissn><abstract>Gastrodia elata Blume (GEB) is a traditional herbal plant that has been
used in Asian countries for centuries as an anticonvulsant, analgesic, and also
as a sedative for treating general paralysis, epilepsy, vertigo, and tetanus.
Although numerous reports have addressed the effects of GEB against degenerative
diseases, no previous study has examined the possible gastroprotective effects
of GEB. Here, we examined the effects of pretreatment with GEB (0.02 ml/g, p.o.)
in a mouse water immersion restraint (WIR) stress-induced gastric lesion model.
Our results revealed that mice pretreated with GEB had significantly fewer gastric
lesions than their respective controls. Moreover, GEB-treated mice showed significant
decreases in serum and gastric nitric oxide (NO) levels to 50 and 28%, respectively.
To examine one possible mechanism underlying this effect, we used reverse transcription-polymerase
chain reaction (RT-PCR) to examine NOS mRNA expression in gastric lesion tissues.
Our results revealed that the mRNA expression of inducible nitric oxide synthase
(iNOS) was reduced by ≈50% in GEB-pretreated mice versus the controls, whereas
the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal
nitric oxide synthase (nNOS) remained unchanged. These findings collectively suggest
that GEB significantly protects the gastric mucosa against WIR-induced gastric
damage, at least in part by decreasing NO levels via suppression of iNOS mRNA
expression.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>17611639</pmid><doi>10.3892/ijmm.20.2.209</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular medicine, 2007-08, Vol.20 (2), p.209-215 |
| issn | 1107-3756 1791-244X |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Animals Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Gastric Mucosa - chemistry Gastric Mucosa - drug effects Gastric Mucosa - pathology Gastrodia Gene Expression Regulation - drug effects Immersion Male Mice Mice, Inbred BALB C Nitric Oxide - analysis Nitric Oxide - blood Nitric Oxide Synthase Type I - genetics Nitric Oxide Synthase Type I - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III Restraint, Physical RNA, Messenger - analysis Stomach Diseases - pathology Stomach Diseases - prevention & control Stress, Physiological |
| title | Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice |
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