In vitro activity of ceftobiprole, daptomycin, linezolid, and vancomycin against methicillin-resistant staphylococci associated with endocarditis and bone and joint infection

Abstract We tested the in vitro activity of 4 antimicrobial agents against methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci recovered from patients with endocarditis or bone and joint infection. Ceftobiprole, daptomycin, linezolid, and vancomycin MIC90 values were 1,...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2007-07, Vol.58 (3), p.363-365
Main Authors: Rouse, Mark S, Steckelberg, James M, Patel, Robin
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Arthritis, Infectious - microbiology
Bacteriology
Biological and medical sciences
Ceftobiprole
Daptomycin
Endocarditis, Bacterial - microbiology
Fundamental and applied biological sciences. Psychology
Humans
Infectious Disease
Internal Medicine
Linezolid
Methicillin Resistance
Microbial Sensitivity Tests
Microbiology
Miscellaneous
MRSA
Osteomyelitis - microbiology
Staphylococcal Infections - microbiology
Staphylococcus
Staphylococcus - drug effects
Staphylococcus - isolation & purification
Staphylococcus aureus
Vancomycin
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Summary:Abstract We tested the in vitro activity of 4 antimicrobial agents against methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci recovered from patients with endocarditis or bone and joint infection. Ceftobiprole, daptomycin, linezolid, and vancomycin MIC90 values were 1, 1, 2, and 1 μg/mL, respectively. Ceftobiprole, daptomycin, linezolid, and vancomycin MBC90 values were 2, 4, ≥128, and 8 μg/mL, respectively. Ceftobiprole MIC and MBC values were ≤2 μg/mL for all isolates tested, with the exception of one methicillin-resistant coagulase-negative Staphylococcus spp isolate. Vancomycin lacked bactericidal activity (defined as an MBC/MIC ratio of ≥32) against 2 methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with bone and joint infection; one of these isolates was additionally daptomycin nonsusceptible (daptomycin MIC, 2 μg/mL). There was one additional daptomycin nonsusceptible (daptomycin MIC, 2 μg/mL) isolate (MRSA associated with bone and joint infection). Ceftobiprole demonstrated in vitro bactericidal activity against all MRSA and methicillin-resistant coagulase-negative staphylococci tested.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2007.02.010