Pain assessment following experimental maxillofacial surgical procedure in sheep

The aim of this study was to investigate the severity and duration of postoperative pain and hyperalgesia in sheep undergoing mandibular reconstructive surgery. Stimulus-evoked sensitivity at the surgical site and an area remote from injury, the ipsilateral and contralateral forelimbs, was measured...

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Bibliographic Details
Published in:Laboratory animals (London) 2007-07, Vol.41 (3), p.345-352
Main Authors: Abu-Serriah, M, Nolan, A.M, Dolan, S
Format: Article
Language:English
Subjects:
analgesics
animal models
Animals
duration
Female
Haptoglobins - analysis
Hyperalgesia - blood
Hyperalgesia - physiopathology
Hyperalgesia - veterinary
laboratory animals
Mandible - surgery
mandibular reconstructive surgery
maxillofacial
Oral Surgical Procedures
pain
Pain Measurement
Pain Threshold
Pain, Postoperative - blood
Pain, Postoperative - physiopathology
Pain, Postoperative - veterinary
physiological response
postoperative pain
Reconstructive Surgical Procedures - veterinary
sheep
Sheep - surgery
surgery
Surgery, Oral
Veterinary Medicine
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Summary:The aim of this study was to investigate the severity and duration of postoperative pain and hyperalgesia in sheep undergoing mandibular reconstructive surgery. Stimulus-evoked sensitivity at the surgical site and an area remote from injury, the ipsilateral and contralateral forelimbs, was measured as objective indicators of altered pain processing in adult female sheep (n = 7). Responses were recorded before surgery and one, two, three, seven and 14 days afterwards. Concentrations of the acute-phase protein haptoglobin were measured in serum as a marker of inflammation before and at one and seven days after surgery. A significant decrease in forelimb mechanical withdrawal thresholds (secondary hyperalgesia) and response thresholds to punctate stimulation of the area surrounding the surgical incision (allodynia) was detected one day after surgery and persisted for at least three days, despite intra- and postoperative analgesic treatment. Concentrations of haptoglobin were significantly increased one day post-surgery, indicating the presence of a significant acute inflammatory response, and returned to pre-surgical concentrations by seven days. These data provide a deeper insight into understanding the impact of surgery in experimental animals, and may assist in formulating more effective analgesic and antihyperalgesic treatment regimens postoperatively.
ISSN:0023-6772
1758-1117
DOI:10.1258/002367707781282794