Anti-gingivitis effect of a dentifrice containing bioactive glass (NovaMin®) particulate

Background: The objective of this pilot clinical trial was to evaluate the anti‐gingivitis and anti‐plaque effects of a dentifrice containing bioactive glass (NovaMin®) compared with a placebo control dentifrice in a 6 weeks clinical study. Methods: The study design was a randomized, double‐blinded,...

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Bibliographic Details
Published in:Journal of clinical periodontology 2006-02, Vol.33 (2), p.86-91
Main Authors: Tai, Bao Jun, Bian, Zhuan, Jiang, Han, Greenspan, David C., Zhong, Jipin, Clark, Arthur E., Du, Min Quan
Format: Article
Language:English
Subjects:
Adult
anti-gingivitis
anti-plaque
bioactive glass
Biocompatible Materials - therapeutic use
Case-Control Studies
Dental Plaque - prevention & control
Dental Plaque Index
Dentifrices - therapeutic use
Dentistry
Double-Blind Method
Female
Follow-Up Studies
Gingival Hemorrhage - prevention & control
Gingivitis - prevention & control
Glass
Humans
Male
Periodontal Index
Pilot Projects
Placebos
Toothbrushing
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Summary:Background: The objective of this pilot clinical trial was to evaluate the anti‐gingivitis and anti‐plaque effects of a dentifrice containing bioactive glass (NovaMin®) compared with a placebo control dentifrice in a 6 weeks clinical study. Methods: The study design was a randomized, double‐blinded, controlled clinical trial. One hundred volunteers took part in the study and were matched for plaque index (PLI), gingival bleeding index (GBI), age and gender. The protocol was reviewed and approved by the Ethical Committee of the University. The subjects received a supragingival prophylaxis to remove all plaque, calculus and extrinsic stain. Following the baseline examination, subjects were instructed to brush with their assigned dentifrice and toothbrush. The PLI and GBI were determined for the baseline and 6 weeks. The data were analysed using a repeated‐measures anova conducted on the two dependent measures to compare the effect between the test and control group. Results: Ninety‐five subjects finished the study. The results showed that the PLI (baseline=1.54, 6 weeks=1.29) and GBI (baseline=1.14, 6 weeks=0.47) were significantly reduced, respectively, over the 6 weeks period in the test group (p
ISSN:0303-6979
1600-051X
DOI:10.1111/j.1600-051X.2005.00876.x