Putative Role of Asymmetric Dimethylarginine in Microvascular Disease of Kidney and Heart in Hypertensive Patients

Background Despite the frequent simultaneous presentation of cardiac and renal dysfunction, the relationship between these pathophysiological processes remains unclear. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase, which has been linked to endothelial d...

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Bibliographic Details
Published in:American journal of hypertension 2008-06, Vol.21 (6), p.650-656
Main Authors: Fujii, Hideki, Takiuchi, Shin, Kawano, Yuhei, Fukagawa, Masafumi
Format: Article
Language:English
Subjects:
Aged
Arginine - analogs & derivatives
Arginine - blood
Arginine - physiology
Carotid Arteries - diagnostic imaging
Echocardiography
Female
Glomerular Filtration Rate
Heart Diseases - physiopathology
Humans
Hypertension - complications
Hypertension - physiopathology
Male
Middle Aged
Renal Insufficiency - physiopathology
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Summary:Background Despite the frequent simultaneous presentation of cardiac and renal dysfunction, the relationship between these pathophysiological processes remains unclear. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase, which has been linked to endothelial dysfunction and atherosclerosis. This study elucidates the relationship between ADMA and intrarenal and coronary microvascular diseases. Methods In this study, we included 66 consecutive hypertensive patients with normal renal function or mild renal insufficiency (creatinine ≤ 1.2 mg/dl). On the basis of their estimated glomerular filtration rate (eGFR), the patients were divided into two groups (normal group, eGFR ≥90 ml/min; renal insufficiency group, eGFR
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1038/ajh.2008.29