The Protective Effect of Bergamot Oil Extract on Lecitine-like OxyLDL Receptor-1 Expression in Balloon Injury-related Neointima Formation

Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved in smooth muscle cell (SMC) proliferation and neointima formation in injured blood vessels. This study evaluates the effect of the nonvolatile fraction (NVF), the antioxidant component of bergamot essential oil (BEO), o...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular pharmacology and therapeutics 2008-06, Vol.13 (2), p.120-129
Main Authors: Mollace, Vincenzo, Ragusa, Salvatore, Sacco, Iolanda, Muscoli, Carolina, Sculco, Francesca, Visalli, Valeria, Palma, Ernesto, Muscoli, Saverio, Mondello, Luigi, Dugo, Paola, Rotiroti, Domenicantonio, Romeo, Francesco
Format: Article
Language:English
Subjects:
Angioplasty, Balloon - adverse effects
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Carotid Stenosis - etiology
Carotid Stenosis - prevention & control
Cell Proliferation - drug effects
Dose-Response Relationship, Drug
Free Radicals - metabolism
Gene Expression Regulation - drug effects
Male
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - metabolism
Oxidative Stress - drug effects
Plant Oils - administration & dosage
Plant Oils - pharmacology
Rats
Rats, Wistar
Scavenger Receptors, Class E - drug effects
Scavenger Receptors, Class E - genetics
Superoxides - metabolism
Tunica Intima - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved in smooth muscle cell (SMC) proliferation and neointima formation in injured blood vessels. This study evaluates the effect of the nonvolatile fraction (NVF), the antioxidant component of bergamot essential oil (BEO), on LOX-1 expression and free radical generation in a model of rat angioplasty. Common carotid arteries injured by balloon angioplasty were removed after 14 days for histopathological, biochemical, and immunohistochemical studies. Balloon injury led to a significant restenosis with SMC proliferation and neointima formation, accompanied by increased expression of LOX-1 receptor, malondialdehyde and superoxide formation, and nitrotyrosine staining. Pretreatment of rats with BEO-NVF reduced the neointima proliferation together with free radical formation and LOX-1 expression in a dose-dependent manner. These results suggest that natural antioxidants may be relevant in the treatment of vascular disorders in which proliferation of SMCs and oxyLDL-related endothelial cell dysfunction are involved.
ISSN:1074-2484
1940-4034
DOI:10.1177/1074248407313821