Post-Infectious Functional Gastrointestinal Disorders in Children

Objective To investigate the development of functional gastrointestinal disorders (FGIDs) after an episode of acute bacterial gastroenteritis (AGE) in children. Study design A cohort study of children 3 to 19 years old with a positive result on a bacterial stool culture. 44 patients in each arm (uni...

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Bibliographic Details
Published in:The Journal of pediatrics 2008-06, Vol.152 (6), p.812-816.e1
Main Authors: Saps, Miguel, MD, Pensabene, Licia, MD, Di Martino, Lucio, MD, Staiano, Annamaria, MD, Wechsler, Joshua, MD, Zheng, Xiaotian, MD, PhD, Di Lorenzo, Carlo, MD
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Bacterial Infections - complications
Biological and medical sciences
Child
Child, Preschool
Cohort Studies
Female
Gastroenteritis - complications
Gastroenteritis - microbiology
Gastrointestinal Diseases - epidemiology
Gastrointestinal Diseases - etiology
General aspects
Humans
Male
Medical sciences
Pediatrics
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Summary:Objective To investigate the development of functional gastrointestinal disorders (FGIDs) after an episode of acute bacterial gastroenteritis (AGE) in children. Study design A cohort study of children 3 to 19 years old with a positive result on a bacterial stool culture. 44 patients in each arm (unidirectional α of 0.05, power of 0.80). Children presenting at two pediatric hospitals (United States and Italy) for AGE who tested positive for bacteria on stool culture (2001-2005) were contacted at least 6 months after the episode. Exposed children were matched with control subjects of similar age and sex consulting to the same hospitals for trauma or well-child visit within 4 weeks of the index case. Symptoms were evaluated with a validated questionnaire for FGIDs assessing pain, diarrhea, and disability. Results 88 patients (46 boys; mean age, 8.1 years; age range, 3-19 years) were recruited. Bacteria included Salmonella (54%), Campylobacter (32%), and Shigella (14%). 36% of exposed patients and 11% of control subjects complained of abdominal pain ( P < .01). 87% had irritable bowel syndrome and 24% had dyspepsia. 56% reported onset of pain following the AGE. Conclusion There is a significant increase in cases of FGIDs after bacterial infections in children.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2007.11.042