Alteration of organized structure of biofilm formed by Staphylococcus epidermidis on soft contact lenses

The effect of a nonsteroidal antiinflammatory drug commercially available in eye drop form (sodium diclofenac) was assayed for its ability to affect biofilms formed by clinical Staphylococcus epidermidis isolates. Biofilms produced by one strain positive for a slime‐associated antigen, suggested to...

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Bibliographic Details
Published in:Journal of biomedical materials research 2000-01, Vol.49 (1), p.53-57
Main Authors: Perilli, Roberto, Marziano, Maria Luisa, Formisano, Giuseppe, Caiazza, Salvatore, Scorcia, Giovanni, Baldassarri, Lucilla
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antigens
Antigens, Bacterial - analysis
Bacteria
Bacterial Adhesion - drug effects
biofilm
Biofilms
Biological and medical sciences
biomaterials
Contact Lenses, Hydrophilic - microbiology
Diclofenac - pharmacology
Diseases of the eye
Drug products
infection
Medical sciences
Microscopy, Electron, Scanning
nonsteroidal antiinflammatory drug
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
slime
Sodium compounds
sodium diclofenac
Space life sciences
Staphylococcus epidermidis
Staphylococcus epidermidis - drug effects
Staphylococcus epidermidis - growth & development
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Summary:The effect of a nonsteroidal antiinflammatory drug commercially available in eye drop form (sodium diclofenac) was assayed for its ability to affect biofilms formed by clinical Staphylococcus epidermidis isolates. Biofilms produced by one strain positive for a slime‐associated antigen, suggested to be expressed by more virulent strains, was not affected by sodium diclofenac treatment. On the other hand, biofilm produced by the slime‐positive, antigen‐negative strain showed dramatic alterations already after short treatments with sodium diclofenac as reported for salicylate and other nonsteroidal drugs. Such results suggest further investigation of the possible use of sodium diclofenac drops in the treatment of ophthalmic infections in soft contact lens wearers. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 49, 53–57, 2000.
ISSN:0021-9304
1097-4636
DOI:10.1002/(SICI)1097-4636(200001)49:1<53::AID-JBM7>3.0.CO;2-C