An exploration of inter-relationships between contact angle, inverse phase gas chromatography and triboelectric charging data

Surfaces of pharmaceutical powders have been assessed using contact angle, inverse phase gas chromatography (IGC) and triboelectric (electrostatic) charging techniques. The suitability of the Dynamic Angle Tester (DAT), an instrument based on the sessile drop technique, in determining contact angles...

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 2000, Vol.9 (3), p.271-276
Main Authors: Ahfat, N.Marilyn, Buckton, Graham, Burrows, Robert, Ticehurst, Martyn D.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Chemistry, Pharmaceutical - instrumentation
Chemistry, Pharmaceutical - methods
Chromatography, Gas - methods
Contact angle
Dioxoles - chemistry
Electrochemistry - methods
Electrostatic charging
General pharmacology
Hydrogen-Ion Concentration
Inverse gas chromatography
Lactose - chemistry
Medical sciences
Pharmacology. Drug treatments
Piperidines - chemistry
Powders
Starch - chemistry
Surface energy
Thermodynamics
Triboelectric
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Summary:Surfaces of pharmaceutical powders have been assessed using contact angle, inverse phase gas chromatography (IGC) and triboelectric (electrostatic) charging techniques. The suitability of the Dynamic Angle Tester (DAT), an instrument based on the sessile drop technique, in determining contact angles and then the surface energy of pharmaceutical powders was assessed. The dispersive components of the surface energy of powders determined from the DAT and IGC method ranked the powders in the same order. The dispersive component values obtained by IGC were, as expected, higher than those from the DAT, due to IGC probing the highest energy sites on the powder surface. IGC and triboelectric studies allow materials to be characterised in terms of their electron donating–accepting tendencies, so inter-relationships between the data from the two techniques were explored. Although the data set was limited, there appeared to be a correlation between the charges developed by the powders on contact with stainless steel and the ratio of the electron-donating to electron-accepting tendencies of the materials as obtained from IGC.
ISSN:0928-0987
1879-0720
DOI:10.1016/S0928-0987(99)00063-9