Lung volume reduction surgery in lieu of pneumonectomy in an infant with severe unilateral pulmonary interstitial emphysema

• Published in: Pediatric pulmonology 2001-05, Vol.31 (5), p.389-393
• Main Authors: Messineo, Antonio, Fusaro, F., Mognato, G., Sabatti, M., D'Amore, E.S.G., Guglielmi, M.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; cystic adenomatoid malformation; Cystic Adenomatoid Malformation of Lung, Congenital - diagnosis; Cystic Adenomatoid Malformation of Lung, Congenital - surgery; Humans; infant; Infant, Newborn; Lung - diagnostic imaging; Lung - surgery; lung volume reduction surgery; Male; Medical sciences; Pneumonectomy; prenatal diagnosis; Pulmonary Emphysema - diagnosis; Pulmonary Emphysema - surgery; pulmonary interstitial emphysema; Radiography; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the respiratory system; Ultrasonography, Prenatal
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.1063

A male infant with a prenatal diagnosis (at 20 weeks' gestation) of cystic adenomatoid malformation was delivered after 38 weeks' gestation (birth weight, 3 kg) and admitted to the neonatal intensive care unit. During the first few days of life, he developed mild respiratory distress; a chest radiograph and computed tomography scan showed multiple cystic areas in the left lower lobe with hyperinflation and herniation of the upper lobe across the midline. At 3 weeks of age, a left lower lobectomy was performed for presumed cystic malformation. To our surprize the pathology reports revealed pulmonary interstitial emphysema. The postoperative chest radiograph was unchanged, and mechanical ventilation was necessary and required progressively increasing ventilatory settings to provide adequate support. High‐frequency oscillatory ventilation and selective right bronchus intubation failed to improve lung function. After 3 weeks, a left thoracotomy was repeated and lung volume reduction was performed with removal of 50' of the peripheral hyperinflated parenchyma. Postoperative recovery was rapid; the child was weaned from the ventilator after 3 days and discharged after 3 weeks. Follow‐up chest X‐rays showed a normally expanded right lung with mediastinal structures back to midline and a small left lung. Favorable results persisted at 3 years of follow‐up. This first and successful experience with lung volume reduction in a neonate suggests that infants who need removal of a large portion of lung parenchyma to achieve adequate ventilation and gas exchange, lung volume reduction surgery should be considered as an alternative to pneumonectomy. Pediatr Pulmonol. 2001; 31:389–393. © 2001 Wiley‐Liss, Inc.