Oxidative Stress and Homocysteine in Coronary Artery Disease

Oxidative stress is present in cardiovascular diseases (CVDs), and hyperhomocysteinemia, an independent risk factor for these diseases, may play a role by inducing production of oxygen free radicals. To evaluate the possible role of homocysteine (Hcy) in inducing oxidative stress in coronary artery...

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Published in:Clinical chemistry (Baltimore, Md.) Md.), 2001-05, Vol.47 (5), p.887-892
Main Authors: Cavalca, Viviana, Cighetti, Giuliana, Bamonti, Fabrizia, Loaldi, Alessandro, Bortone, Luana, Novembrino, Cristina, De Franceschi, Michela, Belardinelli, Romualdo, Guazzi, Maurizio D
Format: Article
Language:English
Subjects:
Angina Pectoris - blood
Angina Pectoris - diagnosis
Angina Pectoris - metabolism
Angina, Unstable - blood
Angina, Unstable - metabolism
Biological and medical sciences
Cardiology. Vascular system
Chronic Disease
Coronary heart disease
Female
Gas Chromatography-Mass Spectrometry
Heart
Homocysteine - blood
Humans
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - diagnosis
Immunoenzyme Techniques
Male
Malondialdehyde - blood
Medical sciences
Middle Aged
Oxidative Stress
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Summary:Oxidative stress is present in cardiovascular diseases (CVDs), and hyperhomocysteinemia, an independent risk factor for these diseases, may play a role by inducing production of oxygen free radicals. To evaluate the possible role of homocysteine (Hcy) in inducing oxidative stress in coronary artery disease (CAD), plasma Hcy was measured in 68 consecutive cardiovascular patients, and plasma malondialdehyde (MDA), both free and total (free + bound), was measured in 40 patients with CAD (18 with chronic stable angina and 22 with unstable angina). As controls, we tested 70 healthy volunteers. Hcy was measured by an immunoenzymatic method and MDA, an index of lipid peroxidation, by gas chromatography-mass spectrometry. Plasma Hcy concentrations were significantly higher in cardiovascular patients than in controls (10.2 vs 8.9 micromol/L; P
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/47.5.887