Prenatal stress is associated with depression-related electroencephalographic sleep changes in adult male rats: A preliminary report

1. 1. Prenatal stress in rats has been shown to produce long-term behavioral, neuroendocrine and neurochemical changes. These changes may model aspects of human depressive illness. 2. 2. In this pilot investigation, adult male offspring exposed to stress in utero and nonstressed controls were studie...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 1999-07, Vol.23 (5), p.929-939
Main Authors: Rao, Uma, McGinty, Dennis J., Shinde, Arvind, McCracken, James T., Poland, Russell E.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Biological and medical sciences
Depression
Depressive Disorder - psychology
development
Disease Models, Animal
Electroencephalography
Electromyography
Female
Fundamental and applied biological sciences. Psychology
Male
Medical sciences
Mood disorders
Personality. Affectivity
Pilot Projects
Polysomnography
Pregnancy
Prenatal Exposure Delayed Effects
prenatal stress
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Rats
Rats, Sprague-Dawley
sleep
Sleep - physiology
Sleep, REM - physiology
Stress
Stress, Psychological - psychology
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Summary:1. 1. Prenatal stress in rats has been shown to produce long-term behavioral, neuroendocrine and neurochemical changes. These changes may model aspects of human depressive illness. 2. 2. In this pilot investigation, adult male offspring exposed to stress in utero and nonstressed controls were studied using 24-hour electroencephalographic sleep recordings. 3. 3. Prenatally stressed animals demonstrated reduced latency to the onset of rapid eye movement (REM) sleep, prolongation of the first REM episode, and diminished slowwave sleep. 4. 4. Although preliminary, the observed changes parallel those seen in studies of human depression. These data further support the face validity of the prenatal stress model as a potential tool for future studies on the pathophysiology of depressive disorder.
ISSN:0278-5846
1878-4216
DOI:10.1016/S0278-5846(99)00036-6