Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats

Cerebral hypoxia is a major component of immediate and secondary cell damage caused by ischemia. Hyperbaric oxygen (HBO) is a potent means to increase the amount of oxygen dissolved in blood plasma. The effectiveness of HBO in clinical and experimental cerebral ischemia, however, is controversial. W...

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Bibliographic Details
Published in:Brain research 2000-01, Vol.853 (1), p.68-73
Main Authors: Veltkamp, Roland, Warner, David S., Domoki, Ferenc, Brinkhous, Ann D., Toole, James F., Busija, David W.
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Behavioral Symptoms - physiopathology
Biological and medical sciences
Blood Gas Analysis
Cerebral Cortex - drug effects
Cerebral Cortex - pathology
Dose-Response Relationship, Drug
Hyperbaric oxygen
Hyperbaric Oxygenation
Hypoxia
Infarction, Middle Cerebral Artery - physiopathology
Ischemic Attack, Transient - physiopathology
Ischemic Attack, Transient - therapy
Male
Medical sciences
Neurology
Oxygen - administration & dosage
Penumbra
Rats
Rats, Wistar
Reperfusion
Stroke
Vascular diseases and vascular malformations of the nervous system
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Summary:Cerebral hypoxia is a major component of immediate and secondary cell damage caused by ischemia. Hyperbaric oxygen (HBO) is a potent means to increase the amount of oxygen dissolved in blood plasma. The effectiveness of HBO in clinical and experimental cerebral ischemia, however, is controversial. We sought to determine whether treatment with HBO initiated early after focal cerebral ischemia-onset protects the brain when experimental conditions such as brain temperature are controlled. Male Wistar rats ( n=57) underwent reversible filament occlusion of the right middle cerebral artery (MCA) for 75 min. Animals were awakened after filament introduction and assessed for presence of forelimb paresis. Rats then underwent a 60-min course of either 100% O 2 at 1.0 atmosphere absolute (ata; control group), HBO 1.5 ata, or HBO 2.5 ata in a customized HBO chamber allowing physiological monitoring and pericranial temperature control. The filament was then removed. Seven days after ischemia, rat behavior was scored from 3–18 (18=normal) and brains were removed for histological analysis of infarct volume. Rats treated with HBO 2.5 ata had better mean±standard deviation (S.D.) behavioral scores (14±2; p
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(99)02250-7