Onset of spinal block is more rapid with isobaric than hyperbaric bupivacaine

To compare isobaric with hyperbaric 9.75 mg bupivacaine injected intrathecally, and to evaluate the effects of subsequent injection of lidocaine 2% into the epidural space. Patients in group 1 (n = 30) received isobaric 9.75 mg bupivacaine and in group 2 (n = 30) hyperbaric 9.75 mg bupivacaine injec...

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Bibliographic Details
Published in:Canadian journal of anesthesia 2000, Vol.47 (1), p.43-46
Main Authors: MARTIN, R, FRIGON, C, CHRETIEN, A, TETRAULT, J.-P
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia
Anesthesia, Spinal
Anesthetics, Local - administration & dosage
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Bupivacaine - administration & dosage
Double-Blind Method
Epidural
Female
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Surgery
Time Factors
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Summary:To compare isobaric with hyperbaric 9.75 mg bupivacaine injected intrathecally, and to evaluate the effects of subsequent injection of lidocaine 2% into the epidural space. Patients in group 1 (n = 30) received isobaric 9.75 mg bupivacaine and in group 2 (n = 30) hyperbaric 9.75 mg bupivacaine injected into the subarachnoid space in a combined spinal-epidural technique. They were undergoing urological, gynecological, orthopedic, gastro-intestinal or vascular surgery. Using a double blind technique, the followings parameters were measured: cutaneous analgesia to pinprick, motor blockade, time for two segment regression, time for complete regression of the motor block, quality of anesthesia. In 12 patients the effect of epidural injections of 3 ml lidocaine 2% was observed. Motor and sensory block developed more rapidly (five minutes) in the isobaric group (P
ISSN:0832-610X
1496-8975
DOI:10.1007/BF03020730