Identification of plasticizers in medical products by a combined direct thermodesorption–cooled injection system and gas chromatography–mass spectrometry

The combination of a new thermodesorption module with a cooled injection system now provides a powerful system for direct analysis of volatile trace compounds in gaseous, liquid and solid samples by gas chromatography–mass spectrometry (GC–MS). As a cooled injection system is used for the cryofocusi...

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Bibliographic Details
Published in:Journal of Chromatography A 1999-06, Vol.847 (1), p.1-7
Main Authors: Wahl, Hans Günther, Hoffmann, Andreas, Häring, Hans-Ulrich, Liebich, Hartmut M
Format: Article
Language:English
Subjects:
Applied sciences
Compounding ingredients
Diethylhexyl phthalate
Diethylhexyl Phthalate - isolation & purification
Exact sciences and technology
Gas Chromatography-Mass Spectrometry - instrumentation
Gas Chromatography-Mass Spectrometry - methods
Hot Temperature
Phthalates
Plasticizers
Plasticizers - analysis
Plasticizers - isolation & purification
Poly(vinyl chloride)
Polymer industry, paints, wood
Renal Dialysis - instrumentation
Syringes
Technology of polymers
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Summary:The combination of a new thermodesorption module with a cooled injection system now provides a powerful system for direct analysis of volatile trace compounds in gaseous, liquid and solid samples by gas chromatography–mass spectrometry (GC–MS). As a cooled injection system is used for the cryofocusing of the desorbed volatiles the GC–MS system still can be used for the regular analysis of liquid samples. Although plasticizers usually are analyzed by GC–MS after solvent extraction, contaminated solvents and glassware are very well known problems. Analysis of plasticizers in plastic materials by direct thermodesorption instead saves time and avoids cross contaminations. Many medical products are made of plasticized polyvinyl chloride. Extraction of the common plasticizer di(2-ethylhexyl) phthalate (DEHP) into blood will occur, and harmful effects of DEHP in the human body have been suggested. We therefore analyzed 21 different plastic devices which are used for various invasive techniques in medicine by direct thermodesorption GC-MS. In some of the plastics up to 30 different components were identified. By far the most common plasticizer found was DEHP, followed by diethyl and dibutyl phthalates.
ISSN:0021-9673
DOI:10.1016/S0021-9673(99)00138-7