Control of a community-wide outbreak of hepatitis A by mass vaccination with inactivated hepatitis A vaccine

The epidemiology and control of hepatitis A virus was investigated during an outbreak of hepatitis A in a village in Israel. Postexposure administration of immune globulin to contacts was ineffective in controlling the outbreak. However, within 2 weeks of starting a mass immunization campaign with h...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2001-03, Vol.20 (3), p.185-187
Main Authors: ZAMIR, C, RISHPON, S, ZAMIR, D, LEVENTHAL, A, RIMON, N, BEN-PORATH, E
Format: Article
Language:English
Subjects:
Antibodies
Arrests
Biological and medical sciences
Child
Child, Preschool
Disease Outbreaks
Disease prevention
Epidemics
Epidemiology
Hepatitis
Hepatitis A
Hepatitis A - epidemiology
Hepatitis A - prevention & control
Hepatitis A Antibodies
Hepatitis A Vaccines - adverse effects
Hepatitis A Vaccines - immunology
Hepatitis A virus
Hepatitis Antibodies - blood
Human viral diseases
Humans
Immunization
Immunoglobulins
Infant
Infections
Infectious diseases
Israel
Medical sciences
Outbreaks
Tropical medicine
Vaccination
Vaccines
Vaccines, Inactivated - immunology
Viral diseases
Viral hepatitis
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Description
Summary:The epidemiology and control of hepatitis A virus was investigated during an outbreak of hepatitis A in a village in Israel. Postexposure administration of immune globulin to contacts was ineffective in controlling the outbreak. However, within 2 weeks of starting a mass immunization campaign with hepatitis A vaccine, the incidence of hepatitis A declined dramatically; the last case occurred 6 weeks after the immunization program began. The study demonstrated that while postexposure administration of immune globulin may diminish but not entirely arrest transmission of hepatitis A virus, active hepatitis A vaccination is a safe and effective intervention that can be used safely in hepatitis A virus antibody-positive children.
ISSN:0934-9723
1435-4373
DOI:10.1007/s100960100461