Oral recurrent human herpes virus infection and bone marrow transplantation survival

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2001-05, Vol.91 (5), p.552-556
• Main Authors: Gomez, Ricardo Santiago, Carneiro, Marcelo Antunes, Souza, Leandro Napier, Victória, Júnia Maria Netto, de Azevedo, Wellington Moraes, De Marco, Luiz, Kalapothakis, Evanguedes
• Format: Article
• Language: English
• Subjects: Acute Disease; Acyclovir - therapeutic use; Adolescent; Adult; Age Factors; Anemia, Aplastic - therapy; Antiviral Agents - therapeutic use; Biological and medical sciences; Bone Marrow Transplantation; Chronic Disease; Dentistry; Female; Graft vs Host Disease - etiology; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Leukemia - therapy; Linear Models; Lymphoma - therapy; Male; Medical sciences; Middle Aged; Multivariate Analysis; Platelet Count; Prognosis; Proportional Hazards Models; Recurrence; Salivary Gland Diseases - etiology; Sex Factors; Stomatitis - etiology; Stomatitis, Herpetic - drug therapy; Stomatitis, Herpetic - etiology; Stomatitis, Herpetic - prevention & control; Survival Rate; Tissue Donors; Transplantation Conditioning; Tropical medicine; Viral diseases; Viral diseases of the respiratory system and ent viral diseases
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1067/moe.2001.112568

Objective: This study was conducted to compare the survival rates of bone marrow transplantation (BMT) patients who were affected with the survival rates of those who were not affected by oral recrudescent human herpes virus-1 infection (HHV-1) after transplantation. Study Design: Fifty-two consecutive patients who underwent BMT were included in the study. The time of death after BMT was displayed, by means of the Kaplan-Meier method, for the following parameters: age and gender of the patient, donor gender, primary disease, stem cells, conditioning regimen, platelet number after day 100, acute and chronic graft-versus-host disease, oral recurrent HHV-1 infection post-BMT, oral lichenoid lesions of graft-versus-host disease, graft-versus-host disease at the salivary glands, parenteral nutrition, and oral mucositis. The data were initially analyzed by means of the log-rank test and then included in the Cox proportional hazards model. Results: The multivariate analysis demonstrated a significance of 5% for only the platelet numbers and oral recurrent HHV-1 infection. Conclusion: The present study provides evidence that platelet numbers below 100,000 cells/mm3 after day 100 and oral recurrent HHV-1 infection are independent negative prognostic variables in BMT patients’ 24-month survival rates. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:552-6)