Effect of dipyridamole on QT dispersion in vasospastic angina pectoris

Life-threatening ventricular arrhythmias have frequently been documented in patients with vasospastic angina. Moreover, the incidence of ventricular arrhythmias has been closely associated with increased QT dispersion. However, the underlying mechanism responsible for this arrhythmogenesis has not b...

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Bibliographic Details
Published in:The American journal of cardiology 1999-10, Vol.84 (7), p.807-810
Main Authors: Ashikaga, Takashi, Nishizaki, Mitsuhiro, Arita, Masataka, Yamawake, Noriyoshi, Suzuki, Makoto, Hashimoto, Yuji, Kishi, Yukio, Numano, Fujio, Hiraoka, Masayasu
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aminophylline - pharmacology
Analysis of Variance
Angina Pectoris - complications
Angina Pectoris - physiopathology
Biological and medical sciences
Cardiotonic Agents - pharmacology
Chest Pain - etiology
Chest Pain - physiopathology
Coronary Vasospasm - complications
Coronary Vasospasm - physiopathology
Dipyridamole - pharmacology
Electrocardiography - drug effects
Electrocardiography. Vectocardiography
Electrodiagnosis. Electric activity recording
Female
Hemodynamics - drug effects
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Vasodilator Agents - pharmacology
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Summary:Life-threatening ventricular arrhythmias have frequently been documented in patients with vasospastic angina. Moreover, the incidence of ventricular arrhythmias has been closely associated with increased QT dispersion. However, the underlying mechanism responsible for this arrhythmogenesis has not been clarified. The effects of dipyridamole and subsequent aminophylline administration on QT dispersion were examined in 35 patients with vasospastic angina and 30 patients with atypical chest pain. None of the patients enrolled in this study revealed any significant stenosis in coronary angiography. QT dispersion during dipyridamole followed by aminophylline administration was compared between the 2 groups. The baseline QT dispersion was similar in both groups (vasospastic angina: 27 ± 8 ms; atypical chest pain: 28 ± 7 ms). No significant changes in QT dispersion were observed in patients with atypical chest pain by dipyridamole (23 ± 9 ms) and subsequent aminophylline administration (23 ± 5 ms). However, the QT dispersion in patients with vasospastic angina increased significantly by dipyridamole administration (53 ± 14 ms, p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00441-5