Anergy during pregnancy

Objective: This study was undertaken to determine whether the prevalence of anergy is higher among pregnant women than among nonpregnant women. Study Design: Sixty human immunodeficiency virus–seronegative women (n = 30 pregnant, n = 30 nonpregnant) from the Duke University Medical Center (Durham, N...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2001-05, Vol.184 (6), p.1090-1092
Main Authors: Jackson, Tina D., Murtha, Amy P.
Format: Article
Language:English
Subjects:
Adult
Anergy
Antigens, Bacterial - immunology
Antigens, Fungal - immunology
Antigens, Viral - immunology
Bacterial diseases
Biological and medical sciences
Candida - immunology
Clonal Anergy - immunology
Female
Human bacterial diseases
Humans
Hypersensitivity, Delayed - immunology
Infectious diseases
Medical sciences
Mumps - immunology
pregnancy
Pregnancy - immunology
Prevalence
Reference Values
Skin Tests
Tuberculin Test
tuberculosis
Tuberculosis and atypical mycobacterial infections
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Summary:Objective: This study was undertaken to determine whether the prevalence of anergy is higher among pregnant women than among nonpregnant women. Study Design: Sixty human immunodeficiency virus–seronegative women (n = 30 pregnant, n = 30 nonpregnant) from the Duke University Medical Center (Durham, North Carolina) clinic were enrolled. Skin tests were performed with purified protein derivative of tuberculin, Candida antigen, mumps antigen, and tetanus toxoid. A power calculation was done to determine adequate sample size, and data were analyzed with the Fisher exact test and the t test. Results: Three women in each group did not have a response to any of the antigens tested, for an anergy prevalence of 10%. Pregnant women were less likely to have a reaction to skin testing with tetanus toxoid than were nonpregnant women (10% vs 40%; P
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2001.114921