Ciprofloxacin in treatment of nosocomial meningitis in neonates and in infants: report of 12 cases and review

Twelve cases of neonatal and infant nosocomial meningitis treated with intravenous ciprofloxacin in doses of 10 to 60 mg/kg/day are described. Four neonates were 21 to 28 days old and eight infants were 2 to 6 months old. Six presented with Gram-negative meningitis: Escherichia coli (2), Salmonella...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 1999-09, Vol.35 (1), p.75-80
Main Authors: Krčméry, V, Filka, J, Uher, J, Kurak, H, Šagát, T, Tuharský, J, Novák, I, Urbanová, T, Kralinský, K, Mateička, F, Krčméryová, T, Jurga, L’, Šulcová, M, Štencl, J, Krúpová, I
Format: Article
Language:English
Subjects:
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Ciprofloxacin - administration & dosage
Ciprofloxacin - therapeutic use
Cross Infection - drug therapy
Female
Follow-Up Studies
Human bacterial diseases
Humans
Infant
Infant, Newborn
Infectious diseases
Injections, Intravenous
Male
Medical sciences
Meningitis, Bacterial - drug therapy
Pharmacology. Drug treatments
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Twelve cases of neonatal and infant nosocomial meningitis treated with intravenous ciprofloxacin in doses of 10 to 60 mg/kg/day are described. Four neonates were 21 to 28 days old and eight infants were 2 to 6 months old. Six presented with Gram-negative meningitis: Escherichia coli (2), Salmonella enteritidis (1), Acinetobacter calcoaceticus (1), two with two organisms, and ( H. influenzae plus Staphylococcus epidermidis, Acinetobacter spp. plus S. epidermidis), and six were attributable to Gram-positive cocci (four S. aureus and two Enterococcus faecalis). Ten cases were cured. In two cases, reversible hydrocephalus appeared that responded to intraventricular punctures. In seven children, no neurologic sequellae appeared after a 2- to 4-year follow-up. One neonate had relapse of meningitis 3 months later and was ultimately cured, but developed a sequellae of psychomotoric retardation. Follow-up varied from 27 months to 10 years. Current published case reports from Medline on quinolone use in meningitis in neonates and infants are reviewed.
ISSN:0732-8893
1879-0070
DOI:10.1016/S0732-8893(99)00052-8