Synonymous codon bias is not caused by mutation bias in G+C-rich genes in humans

It is has been suggested that synonymous codon bias is a consequence of mutation bias in mammals. We tested this hypothesis in humans using single-nucleotide polymorphism data. We found a pattern of polymorphism which was inconsistent with the mutation bias hypothesis in G+C-rich genes. However, the...

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Bibliographic Details
Published in:Molecular biology and evolution 2001-06, Vol.18 (6), p.982-986
Main Authors: Smith, N G, Eyre-Walker, A
Format: Article
Language:English
Subjects:
Base Composition
Codon - genetics
CpG Islands
DNA, Intergenic
GC Rich Sequence
Gene Conversion
Genes - genetics
Humans
Models, Genetic
Mutation
Polymorphism, Single Nucleotide
Selection, Genetic
Sequence Tagged Sites
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Summary:It is has been suggested that synonymous codon bias is a consequence of mutation bias in mammals. We tested this hypothesis in humans using single-nucleotide polymorphism data. We found a pattern of polymorphism which was inconsistent with the mutation bias hypothesis in G+C-rich genes. However, the data were consistent with the action of natural selection or biased gene conversion. Similar patterns of polymorphism were also observed in noncoding DNA, suggesting that natural selection or biased gene conversion may affect large tracts of the human genome.
ISSN:0737-4038
1537-1719
DOI:10.1093/oxfordjournals.molbev.a003899