Understanding the enzymology of archaeal DNA replication: progress in form and function

The analysis of completed archaeal genome sequences led to the identification of a set of approximately 10–20 genes whose protein products were inferred to be involved in chromosomal DNA replication. Until recently, however, little was known of the biochemical properties of these proteins. Here, I r...

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Bibliographic Details
Published in:Molecular microbiology 2001-05, Vol.40 (3), p.520-529
Main Author: MacNeill, Stuart A.
Format: Article
Language:English
Subjects:
DNA Replication
DNA, Archaeal - biosynthesis
Enzymes
Peptide Chain Elongation, Translational
Peptide Initiation Factors
Replication Origin
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Summary:The analysis of completed archaeal genome sequences led to the identification of a set of approximately 10–20 genes whose protein products were inferred to be involved in chromosomal DNA replication. Until recently, however, little was known of the biochemical properties of these proteins. Here, I review recent progress in this area brought about by biochemical and structural analysis. Aside from shedding considerable new light on the molecular machinery of DNA replication in the archaea, the results of these studies also present new opportunities for understanding the molecular events of chromosomal DNA replication in eukaryotic cells.
ISSN:0950-382X
1365-2958
DOI:10.1046/j.1365-2958.2001.02390.x