Loading…

The Hallmarks of Cancer

We foresee cancer research developing into a logical science, where the complexities of the disease, described in the laboratory and clinic, will become understandable in terms of a small number of underlying principles. Some of these principles are even now in the midst of being codified. We discus...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2000-01, Vol.100 (1), p.57-70
Main Authors: Hanahan, Douglas, Weinberg, Robert A
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We foresee cancer research developing into a logical science, where the complexities of the disease, described in the laboratory and clinic, will become understandable in terms of a small number of underlying principles. Some of these principles are even now in the midst of being codified. We discuss one set of them in the present essay: rules that govern the transformation of normal human cells into malignant cancers. We suggest that research over the past decades has revealed a small number of molecular, biochemical, and cellular traits-acquired capabilities-shared by most and perhaps all types of human cancer. Our faith in such simplification derives directly from the teachings of cell biology that virtually all mammalian cells carry a similar molecular machinery regulating their proliferation, differentiation, and death. Several lines of evidence indicate that tumorigenesis in humans is a multistep process and that these steps reflect genetic alterations that drive the progressive transformation cf normal human cells into highly malignant derivatives. Many types of cancers are diagnosed in the human population with an age-dependent incidence implicating four to seven rate-limiting, stochastic events. Pathological analyses of a number of organ sites reveal lesions that appear to represent the intermediate steps in a process through which cells evolve progressively from normalcy via a series of premalignant states into invasive cancers. These observations have been rendered more concrete by a large body of work indicating that the genomes of tumor cells are invariably altered at multiple sites, having suffered disruption through lesions as subtle as point mutations and as obvious as changes in chromosome complement. Transformation of cultured cells is itself a multistep process: rodent cells require at least two introduced genetic changes before they acquire tumorigenic competence, while their human counterparts are more difficult to transform. Transgenic models of tumorigenesis have repeatedly supported the conclusion that tumorigenesis in mice involves multiple rate-limiting steps. Taken together, observations of human cancers and animal models argue that tumor development proceeds via a process formally analogous to Darwinian evolution, in which a succession of genetic changes, each conferring one or another type of growth advantage, leads to the progressive conversion of normal human cells into cancer cells.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)81683-9