Fetal membrane distention: Determination of the intrauterine surface area and distention of the fetal membranes preterm and at term

• Published in: American journal of obstetrics and gynecology 2000-01, Vol.182 (1), p.128-134
• Main Authors: Millar, Lynnae K., Stollberg, Jes, DeBuque, Laurie, Bryant-Greenwood, Gillian
• Format: Article
• Language: English
• Subjects: Amnion - anatomy & histology; Amnion - diagnostic imaging; Biological and medical sciences; Birth Weight; Delivery. Postpartum. Lactation; Disorders; Distention; Extraembryonic Membranes - anatomy & histology; Extraembryonic Membranes - diagnostic imaging; Female; fetal membranes; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; intrauterine surface area; Medical sciences; Placenta - anatomy & histology; Placenta - diagnostic imaging; Pregnancy; Reference Values; Ultrasonography; Uterus - anatomy & histology; Uterus - diagnostic imaging
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/S0002-9378(00)70501-1

Objective: This study was undertaken to obtain an accurate measurement of the intrauterine surface area and the degree of distention of the apposed fetal membranes preterm and at term. Study Design: Serial longitudinal images of the uterus in 23 women between 25 and 41 weeks’ gestation were obtained by ultrasonography. A Mathematica (Wolfram Research, Inc, Champaign, Ill) program assembled a 3-dimensional image and calculated the intrauterine surface area for each patient. The surface areas of the placental amnion and membranes were measured in vitro after delivery. From these measurements the degree of distention of each fetal membrane in vivo was calculated. Results: The mean calculated intrauterine surface areas were as follows: 1037 ± 70 cm2 (25-29 weeks’ gestation, n = 4), 1376 ± 121 cm2 (30-34 weeks’ gestation, n = 4), and 1876 ± 307 cm2 (37-41 weeks’ gestation, n = 15, P = .0021 by Wilcoxon rank sum test). The surface areas of the expelled membranes at 25 to 29, 30 to 34, and 37 to 41 weeks’ gestation were 737 ± 61 cm2, 855 ± 77 cm2, and 1115 ± 149 cm2, respectively. The ratios of intrauterine surface area to the area of the expelled membrane and hence a measure of the degree of distention in vivo were 1.4 ± 0.05 at 25 to 29 weeks’ gestation (n = 4), 1.6 ± 0.2 at 30 to 34 weeks’ gestation (n = 4), and 1.7 ± 0.3 at term (n = 15). Conclusion: The intrauterine surface area in vivo increases during gestation. The surface area of the fetal membranes as measured in vitro increases to a lesser extent. The fetal membranes are therefore distended in vivo. (Am J Obstet Gynecol 2000;182:128-34.)