Cerebral oxygenation is better during mild hypothermic than normothermic cardiopulmonary bypass

Normothermic cardiopulmonary bypass (CPB) has been recently used in cardiac surgery. However, there is a controversy whether there is a difference in incidence of neurological disorder after coronary artery bypass graft (CABG) surgery between normothermic CPB and mild hypothermic CPB. In this study,...

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Bibliographic Details
Published in:Canadian journal of anesthesia 2000-02, Vol.47 (2), p.131-136
Main Authors: OKANO, N, OWADA, R.-I, FUJITA, N, KADOI, Y, SAITO, S, GOTO, F
Format: Article
Language:English
Subjects:
Aged
Anesthesia
Anesthesia depending on type of surgery
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Body Temperature
Brain - metabolism
Cardiopulmonary Bypass
Heart Arrest, Induced
Humans
Hypothermia
Medical sciences
Middle Aged
Oxygen - metabolism
Surgery
Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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Summary:Normothermic cardiopulmonary bypass (CPB) has been recently used in cardiac surgery. However, there is a controversy whether there is a difference in incidence of neurological disorder after coronary artery bypass graft (CABG) surgery between normothermic CPB and mild hypothermic CPB. In this study, we assessed the effects of normothermia and mild hypothermia (32 degrees C) during CPB on jugular oxygen saturation (SjvO2). Twenty patients scheduled for elective CABG surgery were divided into two groups. Group 1 (n = 10) underwent normothermic (>35 degrees C) CPB, and Group 2 (n = 10) underwent mild hypothermic (32 degrees C) CPB. Alpha-stat blood gas regulation was applied. After inducing anesthesia, a 4.0 French fibre optic oximetry oxygen saturation catheter was inserted into the right jugular bulb to monitor SjvO2 continuously throughout anesthesia and surgery. The SjvO2 in the normothermic group was decreased at 20 (41.5+/-2.4%) and 40 min (43.8+/-2.8%) after the onset of CPB compared with control (53.9+/-5.4%, P
ISSN:0832-610X
1496-8975
DOI:10.1007/BF03018848