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Genital Tract Human Immunodeficiency Virus Type 1 (HIV-1) Shedding and Inflammation and HIV-1 env Diversity in Perinatal HIV-1 Transmission
This study sought to identify genital tract characteristics associated with vertical transmission of human immunodeficiency virus type 1 (HIV-1). HIV-1 DNA and RNA, HIV-1 env diversity, and inflammatory cells were quantified in cervicovaginal lavages (CVLs) of 24 women enrolled in the Women and Infa...
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| Published in: | The Journal of infectious diseases 2000-02, Vol.181 (2), p.555-563 |
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| container_end_page | 563 |
| container_issue | 2 |
| container_start_page | 555 |
| container_title | The Journal of infectious diseases |
| container_volume | 181 |
| creator | Panther, L. A. Tucker, L. Xu, C. Tuomala, R. E. Mullins, J. I. Anderson, D. J. |
| description | This study sought to identify genital tract characteristics associated with vertical transmission of human immunodeficiency virus type 1 (HIV-1). HIV-1 DNA and RNA, HIV-1 env diversity, and inflammatory cells were quantified in cervicovaginal lavages (CVLs) of 24 women enrolled in the Women and Infants Transmission Study; 7 women transmitted HIV-1 perinatally. Vaginal candidiasis, HIV-1 culture positivity, levels of HIV-1 DNA and cell-free RNA, and HIV-1 env diversity were significantly higher in the CVLs of transmitters. CVL HIV-1 DNA levels correlated with higher levels of inflammatory cells and cell-free HIV-1 RNA. Of subjects with paired blood and CVL specimens, there was more HIV-1 env heterogeneity between blood and CVLs in transmitters than in nontransmitters. In summary, increased HIV-1 shedding is correlated with a more complex population of HIV-1 quasispecies in the genital tracts of parturient women, which may increase the probability that a fetotropic strain is transmitted. |
| doi_str_mv | 10.1086/315230 |
| format | article |
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A. ; Tucker, L. ; Xu, C. ; Tuomala, R. E. ; Mullins, J. I. ; Anderson, D. J.</creator><creatorcontrib>Panther, L. A. ; Tucker, L. ; Xu, C. ; Tuomala, R. E. ; Mullins, J. I. ; Anderson, D. J.</creatorcontrib><description>This study sought to identify genital tract characteristics associated with vertical transmission of human immunodeficiency virus type 1 (HIV-1). HIV-1 DNA and RNA, HIV-1 env diversity, and inflammatory cells were quantified in cervicovaginal lavages (CVLs) of 24 women enrolled in the Women and Infants Transmission Study; 7 women transmitted HIV-1 perinatally. Vaginal candidiasis, HIV-1 culture positivity, levels of HIV-1 DNA and cell-free RNA, and HIV-1 env diversity were significantly higher in the CVLs of transmitters. CVL HIV-1 DNA levels correlated with higher levels of inflammatory cells and cell-free HIV-1 RNA. Of subjects with paired blood and CVL specimens, there was more HIV-1 env heterogeneity between blood and CVLs in transmitters than in nontransmitters. In summary, increased HIV-1 shedding is correlated with a more complex population of HIV-1 quasispecies in the genital tracts of parturient women, which may increase the probability that a fetotropic strain is transmitted.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315230</identifier><identifier>PMID: 10669339</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS/HIV ; Biological and medical sciences ; Cervix Uteri - immunology ; Cervix Uteri - virology ; Cohort Studies ; Disease transmission ; DNA ; DNA, Viral - analysis ; env gene ; Female ; Gene Products, env - genetics ; Genetic Variation ; Genitalia ; Genitalia, Female - virology ; HIV ; HIV 1 ; HIV Infections - immunology ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - genetics ; HIV-1 - physiology ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Infectious diseases ; Major Articles ; Medical sciences ; Neutrophils - immunology ; Nucleic Acid Heteroduplexes - analysis ; Polymerase Chain Reaction ; Pregnancy ; Pregnancy Complications, Infectious - virology ; Proviruses ; RNA ; RNA, Viral - analysis ; Transmitters ; Vagina - immunology ; Vagina - virology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virus Shedding ; Viruses ; Women</subject><ispartof>The Journal of infectious diseases, 2000-02, Vol.181 (2), p.555-563</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2000 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Feb 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-1d3413817a749c25bbf85bcd13fb576fe682fdaeb40ecd8e1dbb104ab89653f33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1312138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10669339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panther, L. A.</creatorcontrib><creatorcontrib>Tucker, L.</creatorcontrib><creatorcontrib>Xu, C.</creatorcontrib><creatorcontrib>Tuomala, R. E.</creatorcontrib><creatorcontrib>Mullins, J. I.</creatorcontrib><creatorcontrib>Anderson, D. J.</creatorcontrib><title>Genital Tract Human Immunodeficiency Virus Type 1 (HIV-1) Shedding and Inflammation and HIV-1 env Diversity in Perinatal HIV-1 Transmission</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>This study sought to identify genital tract characteristics associated with vertical transmission of human immunodeficiency virus type 1 (HIV-1). HIV-1 DNA and RNA, HIV-1 env diversity, and inflammatory cells were quantified in cervicovaginal lavages (CVLs) of 24 women enrolled in the Women and Infants Transmission Study; 7 women transmitted HIV-1 perinatally. Vaginal candidiasis, HIV-1 culture positivity, levels of HIV-1 DNA and cell-free RNA, and HIV-1 env diversity were significantly higher in the CVLs of transmitters. CVL HIV-1 DNA levels correlated with higher levels of inflammatory cells and cell-free HIV-1 RNA. Of subjects with paired blood and CVL specimens, there was more HIV-1 env heterogeneity between blood and CVLs in transmitters than in nontransmitters. In summary, increased HIV-1 shedding is correlated with a more complex population of HIV-1 quasispecies in the genital tracts of parturient women, which may increase the probability that a fetotropic strain is transmitted.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cervix Uteri - immunology</subject><subject>Cervix Uteri - virology</subject><subject>Cohort Studies</subject><subject>Disease transmission</subject><subject>DNA</subject><subject>DNA, Viral - analysis</subject><subject>env gene</subject><subject>Female</subject><subject>Gene Products, env - genetics</subject><subject>Genetic Variation</subject><subject>Genitalia</subject><subject>Genitalia, Female - virology</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Infectious diseases</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Neutrophils - immunology</subject><subject>Nucleic Acid Heteroduplexes - analysis</subject><subject>Polymerase Chain Reaction</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - virology</subject><subject>Proviruses</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>Transmitters</subject><subject>Vagina - immunology</subject><subject>Vagina - virology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>Virus Shedding</subject><subject>Viruses</subject><subject>Women</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkcGO0zAQhiMEYrsLvAHIQisEh4DHkzjJES2wrbSIFVsqxMVyHBtcEqfYyYo-Ay-N21QFceE00vyf_5nxnySPgL4EWvJXCDlDeieZQY5Fyjng3WRGKWMplFV1kpyGsKaUZsiL-8kJUM4rxGqW_LrUzg6yJUsv1UDmYycdWXTd6PpGG6usdmpLVtaPgSy3G02APJ8vVim8IDffdNNY95VI15CFM63sOjnY3u0be4hod0ve2Fvtgx22xDpyrb11cjdwAuJYFzobQnz3ILlnZBv0w0M9Sz69e7u8mKdXHy4XF6-vUpUxNqTQYAZYQiGLrFIsr2tT5rVqAE2dF9xoXjLTSF1nVKum1NDUNdBM1mXFczSIZ8mzyXfj-x-jDoOICyjdttLpfgyioBXNkbH_glCUFVAsI_j0H3Ddj97FI0S0qaJfxI5uyvcheG3ExttO-q0AKnYhiinECD45uI11p5u_sCm1CJwfABmUbE38Q2XDHw6BwX6rxxO2DkPvjzJSAMrK3XnppNsw6J9HXfrvghdY5GL--YvA9_Priq1uxEf8Dcn0ub0</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Panther, L. A.</creator><creator>Tucker, L.</creator><creator>Xu, C.</creator><creator>Tuomala, R. E.</creator><creator>Mullins, J. I.</creator><creator>Anderson, D. J.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Genital Tract Human Immunodeficiency Virus Type 1 (HIV-1) Shedding and Inflammation and HIV-1 env Diversity in Perinatal HIV-1 Transmission</title><author>Panther, L. A. ; Tucker, L. ; Xu, C. ; Tuomala, R. E. ; Mullins, J. I. ; Anderson, D. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-1d3413817a749c25bbf85bcd13fb576fe682fdaeb40ecd8e1dbb104ab89653f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cervix Uteri - immunology</topic><topic>Cervix Uteri - virology</topic><topic>Cohort Studies</topic><topic>Disease transmission</topic><topic>DNA</topic><topic>DNA, Viral - analysis</topic><topic>env gene</topic><topic>Female</topic><topic>Gene Products, env - genetics</topic><topic>Genetic Variation</topic><topic>Genitalia</topic><topic>Genitalia, Female - virology</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Infectious diseases</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Neutrophils - immunology</topic><topic>Nucleic Acid Heteroduplexes - analysis</topic><topic>Polymerase Chain Reaction</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - virology</topic><topic>Proviruses</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>Transmitters</topic><topic>Vagina - immunology</topic><topic>Vagina - virology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Virus Shedding</topic><topic>Viruses</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panther, L. A.</creatorcontrib><creatorcontrib>Tucker, L.</creatorcontrib><creatorcontrib>Xu, C.</creatorcontrib><creatorcontrib>Tuomala, R. E.</creatorcontrib><creatorcontrib>Mullins, J. I.</creatorcontrib><creatorcontrib>Anderson, D. 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J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genital Tract Human Immunodeficiency Virus Type 1 (HIV-1) Shedding and Inflammation and HIV-1 env Diversity in Perinatal HIV-1 Transmission</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>181</volume><issue>2</issue><spage>555</spage><epage>563</epage><pages>555-563</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>This study sought to identify genital tract characteristics associated with vertical transmission of human immunodeficiency virus type 1 (HIV-1). HIV-1 DNA and RNA, HIV-1 env diversity, and inflammatory cells were quantified in cervicovaginal lavages (CVLs) of 24 women enrolled in the Women and Infants Transmission Study; 7 women transmitted HIV-1 perinatally. Vaginal candidiasis, HIV-1 culture positivity, levels of HIV-1 DNA and cell-free RNA, and HIV-1 env diversity were significantly higher in the CVLs of transmitters. CVL HIV-1 DNA levels correlated with higher levels of inflammatory cells and cell-free HIV-1 RNA. Of subjects with paired blood and CVL specimens, there was more HIV-1 env heterogeneity between blood and CVLs in transmitters than in nontransmitters. In summary, increased HIV-1 shedding is correlated with a more complex population of HIV-1 quasispecies in the genital tracts of parturient women, which may increase the probability that a fetotropic strain is transmitted.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10669339</pmid><doi>10.1086/315230</doi><tpages>9</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 2000-02, Vol.181 (2), p.555-563 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | AIDS/HIV Biological and medical sciences Cervix Uteri - immunology Cervix Uteri - virology Cohort Studies Disease transmission DNA DNA, Viral - analysis env gene Female Gene Products, env - genetics Genetic Variation Genitalia Genitalia, Female - virology HIV HIV 1 HIV Infections - immunology HIV Infections - transmission HIV Infections - virology HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus 1 Human viral diseases Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical Infectious diseases Major Articles Medical sciences Neutrophils - immunology Nucleic Acid Heteroduplexes - analysis Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious - virology Proviruses RNA RNA, Viral - analysis Transmitters Vagina - immunology Vagina - virology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virus Shedding Viruses Women |
| title | Genital Tract Human Immunodeficiency Virus Type 1 (HIV-1) Shedding and Inflammation and HIV-1 env Diversity in Perinatal HIV-1 Transmission |
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