Melatonin in older people with age-related sleep maintenance problems : A comparison with age matched normal sleepers

To determine whether older people with age-related sleep maintenance problems have significantly lower melatonin levels than comparable normal sleepers. Case-control study. A largely urban population, Auckland, New Zealand. People over the age of 65 years, who either slept normally, or had age-relat...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2001-06, Vol.24 (4), p.418-424
Main Authors: BASKETT, Jonathan J, WOOD, Philip C, BROAD, Joanna B, DUNCAN, John R, ENGLISH, Judie, ARENDT, Josephine
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - physiology
Behavioral psychophysiology
Biological and medical sciences
Case-Control Studies
Female
Fundamental and applied biological sciences. Psychology
Hormones and behavior
Humans
Male
Melatonin - blood
Melatonin - urine
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Sleep Wake Disorders - blood
Sleep Wake Disorders - urine
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Summary:To determine whether older people with age-related sleep maintenance problems have significantly lower melatonin levels than comparable normal sleepers. Case-control study. A largely urban population, Auckland, New Zealand. People over the age of 65 years, who either slept normally, or had age-related sleep maintenance problems. Participants were recruited through media advertising, and local interest groups. Initial screening was by mail (Pittsburgh Sleep Quality Index), followed by interviews at a hospital day clinic. Exclusions included those with depression, cognitive impairment, medical and/or environmental problems which might impair sleep. N/A. A metabolite of plasma melatonin, 6-sulphatoxymelatonin (aMT6s) was measured in the urine of 57 normal sleepers, and 53 people with age-related problems over 24 hours in three aliquots: 12:00-19:00h, 19:00-07:00h, 07:00-12:00h. There were clear differences in self reported quality of sleep but no difference in mean aMT6s 24 hour or total night excretory levels, or night/day ratios. Older people with age-related sleep maintenance problems do not have lower melatonin levels than older people reporting normal sleep.
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/24.4.418