Development and application of a biological peptide pump for the study of the in vivo actions of angiotensin peptides

In the past few years, a great deal of interest has been focused on the possibility that angiotensin peptides could have direct effects on target tissues independent of their hemodynamic effects. In addition, there has been much speculation on the potential biological roles of angiotensin peptides o...

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Bibliographic Details
Published in:American journal of hypertension 2001-06, Vol.14 (S3), p.38S-43S
Main Authors: Methot, Danielle, vanKats, Jorge P, Lochard, Nadheige, Tremblay, Fannie, Silversides, David W, Reudelhuber, Timothy L
Format: Article
Language:English
Subjects:
angiotensin II
Angiotensins - physiology
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Experimental diseases
Furin
Humans
Medical sciences
Membrane Transport Proteins
Peptide Fragments - physiology
Peptides - metabolism
Protein Engineering
Renin-angiotensin system
Subtilisins - metabolism
transgenic mice
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Summary:In the past few years, a great deal of interest has been focused on the possibility that angiotensin peptides could have direct effects on target tissues independent of their hemodynamic effects. In addition, there has been much speculation on the potential biological roles of angiotensin peptides other than angiotensin II. Unfortunately, a direct test of these possibilities in whole animals has been difficult due to limitations in existing biological systems. In this review, we describe the characteristics of an engineered protein capable of directing the production of a wide variety of peptides to specific tissues and cell types in transgenic animals and discuss its potential applications.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(01)02068-4