Abnormal signal-averaged electrocardiogram (SAECG) in obesity

Objective: The occurrence of small high‐frequency electrocardiogram (ECG) potentials (1 to 20 μV) seen at the end of the QRS complex and into the ST segment have been correlated with increased risk for ventricular arrhythmias and sudden cardiac death. Computer‐assisted analysis of these “late potent...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2000-01, Vol.8 (1), p.20-28
Main Authors: Lalani, A.P, Kanna, B, John, J, Ferrick, K.J, Huber, M.S, Shapiro, L.E
Format: Article
Language:English
Subjects:
arrhythmia
body composition
Body Mass Index
Diabetes Mellitus - physiopathology
electric potential
Electrocardiography
heart diseases
Humans
hypertension
Hypertension - complications
Hypertension - physiopathology
late potentials
Logistic Models
Male
Middle Aged
obesity
Obesity - complications
Obesity - physiopathology
signal‐averaged electrocardiography
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Summary:Objective: The occurrence of small high‐frequency electrocardiogram (ECG) potentials (1 to 20 μV) seen at the end of the QRS complex and into the ST segment have been correlated with increased risk for ventricular arrhythmias and sudden cardiac death. Computer‐assisted analysis of these “late potentials” by signal‐averaged electrocardiography (SAECG) has been studied and utilized to predict the likelihood of ventricular arrhythmias in various clinical states. Obesity is associated with significant cardiovascular morbidity and sudden death. Ventricular arrhythmias are postulated causes. We studied the occurrence of late potentials in a randomly selected group of obese patients and healthy volunteers. Research Methods and Procedures: We performed SAECG on 105 subjects. Of these, 62 were obese ambulatory patients with body mass index (BMI) of >30 kg/m2, whereas 43 were healthy asymptomatic volunteers with a BMI of 38 ms, and root‐mean‐square voltage 50 kg/m2). Multiple logistic regression analysis shows that BMI is an independent predictor variable of abnormal SAECG results in obese patients (n = 62) with BMI of >30kg/m2 as well as in all study subjects (n = 105). BMI also predicts abnormality of each abnormal SAECG criterion in both obese and all subjects. Hypertension was found to influence the QRS duration alone in obese and all subjects. Discussion: Obesity is associated with increased occurrence of abnormal SA
ISSN:1071-7323
1930-7381
1550-8528
1930-739X
DOI:10.1038/oby.2000.4