Fetal 'space-suit' hydrops in the first trimester: differentiating risk for chromosome abnormalities by delineating characteristics of nuchal translucency

Detecting first trimester fetuses with pan‐body hydrops, giving the appearance of a ‘space‐suit,’ is associated with a marked increased risk for chromosome abnormalities. In 30 consecutive fetuses prospectively characterized by space‐suit hydrops, detected at or before 13.9 weeks' gestation, 26...

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Bibliographic Details
Published in:Prenatal diagnosis 2000-01, Vol.20 (1), p.30-32
Main Authors: Shulman, Lee P., Phillips, Owen P., Emerson, Donald S., Felker, Richard E., Tharapel, Avirachan T.
Format: Article
Language:English
Subjects:
Abortion, Therapeutic
Biological and medical sciences
Chorionic Villi Sampling
Chromosome Aberrations
chromosome abnormalities
Cytogenetic Analysis
Female
first trimester
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Hydrops Fetalis - diagnostic imaging
Hydrops Fetalis - genetics
Management. Prenatal diagnosis
Medical sciences
Neck - diagnostic imaging
nuchal translucency
Pregnancy
Pregnancy. Fetus. Placenta
prenatal diagnosis
Prospective Studies
Risk Factors
Twins
Ultrasonography, Prenatal
ultrasound
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Summary:Detecting first trimester fetuses with pan‐body hydrops, giving the appearance of a ‘space‐suit,’ is associated with a marked increased risk for chromosome abnormalities. In 30 consecutive fetuses prospectively characterized by space‐suit hydrops, detected at or before 13.9 weeks' gestation, 26 (86.7%) were characterized by chromosome abnormalities. However, as opposed to the preponderance of autosome abnormalities among first‐trimester fetuses with prominent nuchal translucencies, 15 of the 26 fetuses (57.7%) with abnormal complements were characterized by sex chromosome aneuploidies. Genetic counselling and consideration of invasive prenatal testing is warranted when space‐suit hydrops is detected in the first trimester. Copyright © 2000 John Wiley & Sons, Ltd.
ISSN:0197-3851
1097-0223
DOI:10.1002/(SICI)1097-0223(200001)20:1<30::AID-PD750>3.0.CO;2-9