Left ventricular function and autonomic nervous system balance during two different stages of the menstrual cycle

We studied the left ventricular function and cardiac autonomic nervous system balance variations during two different stages of the menstrual cycle. These two variables, as well as plasmatic estradiol and progesterone concentrations, were measured in a drug-free state in 20 women (29±6 year-old) wit...

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Bibliographic Details
Published in:International journal of cardiology 2000-02, Vol.72 (3), p.243-246
Main Authors: Fuenmayor, Abdel J., Ramı́rez, Leonardo, Fuenmayor, Abdel M.
Format: Article
Language:English
Subjects:
Adult
Autonomic Nervous System - physiology
Biological and medical sciences
Echocardiography, Doppler
Estradiol - blood
Female
Follicular Phase - physiology
Fundamental and applied biological sciences. Psychology
Heart
Heart - innervation
Humans
Left ventricular function
Luteal Phase - physiology
Menstrual cycle
Progesterone - blood
Tropical medicine
Valsalva Maneuver - physiology
Valsalva manoeuvre
Ventricular Function, Left - physiology
Vertebrates: cardiovascular system
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Summary:We studied the left ventricular function and cardiac autonomic nervous system balance variations during two different stages of the menstrual cycle. These two variables, as well as plasmatic estradiol and progesterone concentrations, were measured in a drug-free state in 20 women (29±6 year-old) with regular menstrual periods. A clinical evaluation, an echo-Doppler and a Valsalva manoeuvre were performed in all the patients on the third day of their menstrual cycle (follicular phase) and three days prior to their next menstrual cycle (luteinizing phase). When comparing the results obtained in these two phases, a statistically significant increase was put forward in plasmatic estradiol (50.6±24 vs. 127.3±52.8 pg/ml) and progesterone (0.37±0.42 vs. 11.92±10.8 ng/ml) concentrations, Valsalva index (1.55±0.22 vs. 1.67±0.33; P=0.044) and E/ A mitral wave ratio (1.63±0.36 vs.1.75±0.35, P=0.02). The right and left atrial volumes, left ventricular volumes and ejection fraction were similar in the two menstrual phases studied. We conclude that the autonomic nervous system balance and the left ventricular diastolic function suffer significant changes during the luteinizing phase of the menstrual cycle in normal women.
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(99)00193-X