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Maternal serum levels of macrophage colony-stimulating factor are associated with adverse pregnancy outcome

Objective: The aim of this study was the measurement of maternal serum levels of M-CSF throughout pregnancy, in a low risk obstetrical population, to examine the relationship of M-CSF and pregnancy outcome. Study design: Maternal serum was obtained at various stages of pregnancy and post partum, M-C...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2000-03, Vol.89 (1), p.19-25
Main Authors: Keith, James C., Pijnenborg, Robert, Luyten, Catherine, Spitz, Bernard, Schaub, Robert, Van Assche, F.Andre
Format: Article
Language:English
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Summary:Objective: The aim of this study was the measurement of maternal serum levels of M-CSF throughout pregnancy, in a low risk obstetrical population, to examine the relationship of M-CSF and pregnancy outcome. Study design: Maternal serum was obtained at various stages of pregnancy and post partum, M-CSF levels were measured by ELISA, pertinent clinical data tabulated, and pregnancy outcome was determined. Results: In 564 pregnancies studied, 22% of 260 nulliparous pregnancies and 10% of 304 multiparous pregnancies were hypertensive. Preeclampsia occurred in 1.5% of nulliparous and in 1% of the multiparous women. In apparently normal pregnancies with good outcome, M-CSF levels rose throughout pregnancy. No cases of preeclampsia occurred if maternal serum M-CSF levels increased more than 100% throughout pregnancy. Conclusions: This study suggests that absolute levels and relative changes in maternal serum M-CSF levels during pregnancy are associated with adverse pregnancy outcomes.
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(99)00154-2