Lifestyle Factors and Plasma Homocysteine Concentrations in a General Population Sample

The authors cross-sectionally investigated the extent to which coffee, tea, and alcohol consumption, physical activity, and smoking were associated with nonfasting total plasma homocysteine concentrations in a random sample of 3,025 Dutch adults aged 20–65 years from a population-based cohort examin...

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Bibliographic Details
Published in:American journal of epidemiology 2001-07, Vol.154 (2), p.150-154
Main Authors: Bree, Angelika de, Verschuren, W. M. Monique, Blom, Henk J., Kromhout, Daan
Format: Article
Language:English
Subjects:
Adult
Aged
alcohol drinking
Alcohol Drinking - adverse effects
Analysis of Variance
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
cardiovascular diseases
coffee
Coffee - adverse effects
Cross-Sectional Studies
Diet
Diet Surveys
Exercise
Female
Folic Acid - therapeutic use
homocysteine
Homocysteine - blood
Humans
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - epidemiology
Hyperhomocysteinemia - etiology
Hyperhomocysteinemia - prevention & control
Life Style
Linear Models
Male
Medical sciences
Middle Aged
Miscellaneous
Netherlands - epidemiology
Sampling Studies
smoking
Smoking - adverse effects
Surveys and Questionnaires
Vitamin B Complex - therapeutic use
Citations: Items that cite this one
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Summary:The authors cross-sectionally investigated the extent to which coffee, tea, and alcohol consumption, physical activity, and smoking were associated with nonfasting total plasma homocysteine concentrations in a random sample of 3,025 Dutch adults aged 20–65 years from a population-based cohort examined in 1993–1996 (n = 19,066). The lifestyle factors most strongly associated with plasma total homocysteine level were smoking (positive), alcohol drinking (negative), and coffee consumption (positive). The smoking effect was most prominent in women, and the alcohol effect was most pronounced in men. Data indicated that independently of other lifestyle factors, age, and intake of folate and B vitamin supplements, a change in lifestyle could result in a 0.1- to 1.7-μmol/liter change in plasma total homocysteine level. The authors conclude that lifestyle changes could result in a public-health-relevant change in plasma total homocysteine concentrations.
ISSN:0002-9262
1476-6256
0002-9262
DOI:10.1093/aje/154.2.150