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Single-fiber myosin heavy chain polymorphism during postnatal development: modulation by hypothyroidism
Department of Physiology and Biophysics and Orthopaedics, College of Medicine, University of California, Irvine, California 92697 The primary objective of this study was to follow the developmental time course of myosin heavy chain (MHC) isoform transitions in single fibers of the rodent plantaris m...
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| Published in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-04, Vol.278 (4), p.1099-R1106 |
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| container_end_page | R1106 |
| container_issue | 4 |
| container_start_page | 1099 |
| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 278 |
| creator | di Maso, Nick A Caiozzo, Vincent J Baldwin, Kenneth M |
| description | Department of Physiology and Biophysics and Orthopaedics, College of
Medicine, University of California, Irvine, California
92697
The primary objective of this study was
to follow the developmental time course of myosin heavy chain (MHC)
isoform transitions in single fibers of the rodent plantaris muscle.
Hypothyroidism was used in conjunction with single-fiber analyses to
better describe a possible linkage between the neonatal and fast type
IIB MHC isoforms during development. In contrast to the general concept that developmental MHC isoform transitions give rise to muscle fibers
that express only a single MHC isoform, the single-fiber analyses
revealed a very high degree of MHC polymorphism throughout postnatal
development. In the adult state, MHC polymorphism was so pervasive that
the rodent plantaris muscles contained ~12-15 different pools of
fibers (i.e., fiber types). The degree of polymorphism observed at the
single-fiber level made it difficult to determine specific
developmental schemes analogous to those observed previously for the
rodent soleus muscle. However, hypothyroidism was useful in that it
confirmed a possible link between the developmental regulation of the
neonatal and fast type IIB MHC isoforms.
myosin heavy chain isoforms; electrophoresis; neonatal; plantaris
muscle |
| doi_str_mv | 10.1152/ajpregu.2000.278.4.R1099 |
| format | article |
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Medicine, University of California, Irvine, California
92697
The primary objective of this study was
to follow the developmental time course of myosin heavy chain (MHC)
isoform transitions in single fibers of the rodent plantaris muscle.
Hypothyroidism was used in conjunction with single-fiber analyses to
better describe a possible linkage between the neonatal and fast type
IIB MHC isoforms during development. In contrast to the general concept that developmental MHC isoform transitions give rise to muscle fibers
that express only a single MHC isoform, the single-fiber analyses
revealed a very high degree of MHC polymorphism throughout postnatal
development. In the adult state, MHC polymorphism was so pervasive that
the rodent plantaris muscles contained ~12-15 different pools of
fibers (i.e., fiber types). The degree of polymorphism observed at the
single-fiber level made it difficult to determine specific
developmental schemes analogous to those observed previously for the
rodent soleus muscle. However, hypothyroidism was useful in that it
confirmed a possible link between the developmental regulation of the
neonatal and fast type IIB MHC isoforms.
myosin heavy chain isoforms; electrophoresis; neonatal; plantaris
muscle</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.2000.278.4.R1099</identifier><identifier>PMID: 10749800</identifier><language>eng</language><publisher>Legacy CDMS</publisher><subject>Age Factors ; Animals ; Electrophoresis, Polyacrylamide Gel ; Female ; Gene Expression Regulation, Developmental ; Hypothyroidism - genetics ; Hypothyroidism - metabolism ; Isomerism ; Life Sciences (General) ; Muscle Development ; Muscle Fibers, Skeletal - chemistry ; Muscle Fibers, Skeletal - physiology ; Muscle, Skeletal - chemistry ; Muscle, Skeletal - cytology ; Muscle, Skeletal - growth & development ; Myosin Heavy Chains - chemistry ; Myosin Heavy Chains - genetics ; Polymorphism, Genetic ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Space life sciences ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2000-04, Vol.278 (4), p.1099-R1106</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-6030b1292a78f755488a2014153f58855b0adcaf2d887326561fb0c24384474b3</citedby><cites>FETCH-LOGICAL-c422t-6030b1292a78f755488a2014153f58855b0adcaf2d887326561fb0c24384474b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10749800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>di Maso, Nick A</creatorcontrib><creatorcontrib>Caiozzo, Vincent J</creatorcontrib><creatorcontrib>Baldwin, Kenneth M</creatorcontrib><title>Single-fiber myosin heavy chain polymorphism during postnatal development: modulation by hypothyroidism</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>Department of Physiology and Biophysics and Orthopaedics, College of
Medicine, University of California, Irvine, California
92697
The primary objective of this study was
to follow the developmental time course of myosin heavy chain (MHC)
isoform transitions in single fibers of the rodent plantaris muscle.
Hypothyroidism was used in conjunction with single-fiber analyses to
better describe a possible linkage between the neonatal and fast type
IIB MHC isoforms during development. In contrast to the general concept that developmental MHC isoform transitions give rise to muscle fibers
that express only a single MHC isoform, the single-fiber analyses
revealed a very high degree of MHC polymorphism throughout postnatal
development. In the adult state, MHC polymorphism was so pervasive that
the rodent plantaris muscles contained ~12-15 different pools of
fibers (i.e., fiber types). The degree of polymorphism observed at the
single-fiber level made it difficult to determine specific
developmental schemes analogous to those observed previously for the
rodent soleus muscle. However, hypothyroidism was useful in that it
confirmed a possible link between the developmental regulation of the
neonatal and fast type IIB MHC isoforms.
myosin heavy chain isoforms; electrophoresis; neonatal; plantaris
muscle</description><subject>Age Factors</subject><subject>Animals</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Hypothyroidism - genetics</subject><subject>Hypothyroidism - metabolism</subject><subject>Isomerism</subject><subject>Life Sciences (General)</subject><subject>Muscle Development</subject><subject>Muscle Fibers, Skeletal - chemistry</subject><subject>Muscle Fibers, Skeletal - physiology</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Myosin Heavy Chains - chemistry</subject><subject>Myosin Heavy Chains - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Space life sciences</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp1kM1u1TAUhC0EoreFN0DIK3YJ_k2c7lBFoVIlJChry0mcxJUTB9sp-O3xJRd0N6xseWbOHH8AQIxKjDl5rx5Xr8etJAihktSiZOVXjJrmGThkmRSYNeg5OCBa0aLCuLkAlyE8ZjOjjL4EFxjVrBEIHcD4zSyj1cVgWu3hnFwwC5y0ekqwm1S-r86m2fl1MmGG_eazPb-FuKioLOz1k7ZunfUSr-Hs-s2qaNwC2wSntLo4Je9Mn6OvwItB2aBfn84r8P3248PN5-L-y6e7mw_3RccIiUWFKGoxaYiqxVBzzoRQBGGGOR24EJy3SPWdGkgvRE1JxSs8tKgjjArGatbSK_Bun7t692PTIcrZhE5bqxbttiBrjFAexrNR7MbOuxC8HuTqzax8khjJI2R5giyPkGWGLJn8AzlH3546tnbW_Vlwp5oNb3bDooKSS_ThOIQd_1FhkeXrXZ7MOP00Xst1SsE468YkbzdrH_Sv-Lf-rFiu_ZDD5f_D_1Y-2_Y36xaqPg</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>di Maso, Nick A</creator><creator>Caiozzo, Vincent J</creator><creator>Baldwin, Kenneth M</creator><scope>CYE</scope><scope>CYI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Single-fiber myosin heavy chain polymorphism during postnatal development: modulation by hypothyroidism</title><author>di Maso, Nick A ; Caiozzo, Vincent J ; Baldwin, Kenneth M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-6030b1292a78f755488a2014153f58855b0adcaf2d887326561fb0c24384474b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Hypothyroidism - genetics</topic><topic>Hypothyroidism - metabolism</topic><topic>Isomerism</topic><topic>Life Sciences (General)</topic><topic>Muscle Development</topic><topic>Muscle Fibers, Skeletal - chemistry</topic><topic>Muscle Fibers, Skeletal - physiology</topic><topic>Muscle, Skeletal - chemistry</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Myosin Heavy Chains - chemistry</topic><topic>Myosin Heavy Chains - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Space life sciences</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>di Maso, Nick A</creatorcontrib><creatorcontrib>Caiozzo, Vincent J</creatorcontrib><creatorcontrib>Baldwin, Kenneth M</creatorcontrib><collection>NASA Scientific and Technical Information</collection><collection>NASA Technical Reports Server</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>di Maso, Nick A</au><au>Caiozzo, Vincent J</au><au>Baldwin, Kenneth M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-fiber myosin heavy chain polymorphism during postnatal development: modulation by hypothyroidism</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>278</volume><issue>4</issue><spage>1099</spage><epage>R1106</epage><pages>1099-R1106</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract>Department of Physiology and Biophysics and Orthopaedics, College of
Medicine, University of California, Irvine, California
92697
The primary objective of this study was
to follow the developmental time course of myosin heavy chain (MHC)
isoform transitions in single fibers of the rodent plantaris muscle.
Hypothyroidism was used in conjunction with single-fiber analyses to
better describe a possible linkage between the neonatal and fast type
IIB MHC isoforms during development. In contrast to the general concept that developmental MHC isoform transitions give rise to muscle fibers
that express only a single MHC isoform, the single-fiber analyses
revealed a very high degree of MHC polymorphism throughout postnatal
development. In the adult state, MHC polymorphism was so pervasive that
the rodent plantaris muscles contained ~12-15 different pools of
fibers (i.e., fiber types). The degree of polymorphism observed at the
single-fiber level made it difficult to determine specific
developmental schemes analogous to those observed previously for the
rodent soleus muscle. However, hypothyroidism was useful in that it
confirmed a possible link between the developmental regulation of the
neonatal and fast type IIB MHC isoforms.
myosin heavy chain isoforms; electrophoresis; neonatal; plantaris
muscle</abstract><cop>Legacy CDMS</cop><pmid>10749800</pmid><doi>10.1152/ajpregu.2000.278.4.R1099</doi></addata></record> |
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| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2000-04, Vol.278 (4), p.1099-R1106 |
| issn | 0363-6119 1522-1490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71001535 |
| source | American Physiological Society Journals |
| subjects | Age Factors Animals Electrophoresis, Polyacrylamide Gel Female Gene Expression Regulation, Developmental Hypothyroidism - genetics Hypothyroidism - metabolism Isomerism Life Sciences (General) Muscle Development Muscle Fibers, Skeletal - chemistry Muscle Fibers, Skeletal - physiology Muscle, Skeletal - chemistry Muscle, Skeletal - cytology Muscle, Skeletal - growth & development Myosin Heavy Chains - chemistry Myosin Heavy Chains - genetics Polymorphism, Genetic Pregnancy Rats Rats, Sprague-Dawley Space life sciences Thyroxine - blood Triiodothyronine - blood |
| title | Single-fiber myosin heavy chain polymorphism during postnatal development: modulation by hypothyroidism |
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