Minimal Model Analyses of Beta Cell Secretion, Insulin Sensitivity and Glucose Effectiveness in Glucose Tolerant, Non-diabetic First-Degree Relatives of Ghanaian Patients with Type 2 Diabetes and Healthy Control Subjects

Objective: We have examined the importance of positive family history of type 2 diabetes on serum glucose, insulin sensitivity, and beta cell secretion in native West Africans (Ghanaians) who reside in their native country. Research and Methods: We evaluated the beta cell secretion, insulin secretio...

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Bibliographic Details
Published in:Ethnicity & disease 2001, Vol.11 (2), p.201-210
Main Authors: Amoah, Albert G. B., Owusu, Samuel K., Ayittey, Osa Mensah, Schuster, Dara P., Osei, Kwame
Format: Article
Language:English
Subjects:
Adult
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - genetics
Female
Ghana
Glucose Tolerance Test
Humans
Hyperinsulinism - ethnology
Hyperinsulinism - genetics
Insulin Resistance - genetics
Male
Original Reports: Clinical Research
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Summary:Objective: We have examined the importance of positive family history of type 2 diabetes on serum glucose, insulin sensitivity, and beta cell secretion in native West Africans (Ghanaians) who reside in their native country. Research and Methods: We evaluated the beta cell secretion, insulin secretion, insulin sensitivity (Si), and glucose effectiveness (Sg) in 42 healthy non-diabetic first-degree relatives of Ghanaian patients with type 2 diabetes (26 females and 16 males) and in 22 healthy control subjects without a family history of type 2 diabetes (12 females and 10 males) living in Accra, Ghana, West Africa. A standard oral glucose tolerance test (OGTT) and a frequently sampled intravenous glucose tolerance (FSIGT) test were performed in each subject. Si and Sg were measured using Bergman's minimal model method. Results: During oral glucose challenge, fasting and postprandial serum glucose levels were not significantly different between the relatives and healthy controls. Mean serum insulin and c-peptide responses after oral glucose tolerance test at t = 60, 90 and 120 minutes (P
ISSN:1049-510X
1945-0826